Der Anaesthesist

, Volume 56, Issue 5, pp 482–484 | Cite as

Neue Überlegungen zu Entzündung und Gerinnung

Medizin aktuell

Zusammenfassung

Entzündung ist der Abwehrmechanismus des Wirtes gegen Infektionen oder Traumata. In der Klinik spielen nichtinfektiöse Entzündungen, eine Aktivierung der Gerinnungskaskade sowie eine Verschlechterung der endothelialen Funktion eine wichtige Rolle in der Kardiologie (z. B. bei der perkutanen transluminalen koronaren Angioplastie, PTCA), in der Intensivmedizin (z. B. beim Polytrauma), Herz- (z. B. bei der extrakorporalen Zirkulation) und Gefäßchirurgie (z. B. bei Reperfusionverletzung). Entgleiste Entzündungen sind hauptverantwortlich für den oft fatalen Verlauf von Krankheiten wie Herzinfarkt, Sepsis, hämorrhagisches Fieber (Ebola, Dengue), Organabstoßung und Autoimmunerkrankungen. Weltweit werden große Anstrengungen unternommen, die Regulation der Entzündung zu verstehen, um letztlich Medikamente zu entwickeln, die die pathologische Entzündungsreaktion modulieren können.

Schlüsselwörter

Entzündung Gerinnung Trauma Sepsis Herzinfarkt 

New reflections on inflammation and coagulation

Abstract

Inflammation is the host’s defense mechanism to infection or injury, including surgical procedures. In the clinical setting non-infectious inflammation, activation of the coagulation cascade and deterioration of endothelial function play an important role in cardiology (e.g. percutaneous transluminal coronary angioplasty, PTCA), intensive care medicine (e.g. polytrauma), cardiac (e.g. extracorporal circulation) and vascular surgery (e.g. reperfusion injury). Imbalances in the inflammatory response are mainly responsible for the often fatal course in conditions such as myocardial infarction, sepsis, hemorrhagic fever (ebola, dengue), graft rejection and autoimmune diseases. Great efforts are being undertaken worldwide to understand the regulation of inflammation in order to develop new drugs which can modulate the pathologic inflammation reaction.

Keywords

Inflammation Coagulation Trauma Sepsis Myocardial infarction 

Notes

Interessenkonflikt

Keine Angaben.

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Copyright information

© Springer Medizin Verlag 2007

Authors and Affiliations

  1. 1.Dept. of Anaesthesia, BHIBristol Royal InfirmaryBristolUnited Kingdom

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