Advertisement

Uro-News

, Volume 23, Issue 2, pp 34–36 | Cite as

Bakterien in der Blase

Urinmikrobiom und überaktive Blase — besteht ein Zusammenhang?

  • Elke HeßdörferEmail author
Fortbildung
  • 2 Downloads

17 Jahre nach Einführung des Begriffes „overactive bladder“ ist trotz vielfältiger Therapieoptionen die Effektivität der Behandlungserfolge gegenüber Placebo immer noch ernüchternd. Hohe Therapieabbruchraten und unzufriedene Patienten sind die enttäuschende Bilanz. Haben wir etwas übersehen? Viele neue Aspekte und Komorbiditäten kommen ins Spiel — auch die Rolle des Urinmikrobioms steht im Fokus.

Literatur

  1. 1.
    Human Microbiome Project Consortium. A framework for human microbiome research. Nature. 2012; 486: 215–21Google Scholar
  2. 2.
    Siddiqui H et al. Assessing diversity of the female urine microbiota by high throughput sequencing of 16S rDNA amplicons. BMC Microbiol. 2011; 11: 244CrossRefGoogle Scholar
  3. 3.
    Wolfe AJ et al. Evidence of uncultivated bacteria in the adult female bladder. J. Clin. Microbiol. 2012; 50: 1376–83CrossRefGoogle Scholar
  4. 4.
    Hilt EE et al. Urine is not sterile: use of enhanced urine culture techniques to detect resident bacterial flora in the adult female bladder. J Clin Microbiol. 2014; 52: 871–6CrossRefGoogle Scholar
  5. 5.
    Pearce MM et al. The female urinary microbiome: a comparison of women with and without urgency urinary incontinence. MBio. 2014; e01283–14Google Scholar
  6. 6.
    Pearce MM et al. The female urinary microbiota in urgency urinary incontinence. Am J Obstet Gynecol. 2015; 213: 347.e1–11CrossRefGoogle Scholar
  7. 7.
    Thomas-White KJ et al. Incontinence medication response relates to the female urinary microbiota. Int Urogynecol J. 2016; 37: 723–33CrossRefGoogle Scholar
  8. 8.
    Karstens L et al. Does the urinary microbiome play a role in urgency urinary incontinence and its severity? Front Cell Infect Microbiol. 2016; 6: 78CrossRefGoogle Scholar
  9. 9.
    Wu P et al. Urinary Microbiome and psychological factors in women with overactive bladder, Front Cell Infect Microbiol. 2017; 7: 488CrossRefGoogle Scholar
  10. 10.
    Thomas-White KJ et al. Culturing of female bladder bacteria reveals an interconnected urogenital microbiota. Nat Commun. 2018; 9: 1557CrossRefGoogle Scholar
  11. 11.
    Siddiqui H et al. Alterations of microbiota from women with interstitial cystitis. BMC Microbiol. 2012; 12: 205CrossRefGoogle Scholar
  12. 12.
    Abernethy MG et al. Urinary microbiome and cytokine levels in women with interstitial cystitis. Obstet Gynecol. 2017; 129: 500–6CrossRefGoogle Scholar
  13. 13.
    Nelson DE et al. Characteristic male urin microbiomes associate with asymptomatic sexually transmitted infection. PLoS One. 2010; 5: e14116CrossRefGoogle Scholar
  14. 14.
    Shoskes DA et al. The urinary microbiome differs significantly between patients with chronic prostatitis/chronic pelvic pain syndrome and controls as well as between patients with different clinical phenotypes. Urology. 2016; 92: 26–32CrossRefGoogle Scholar

Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2019

Authors and Affiliations

  1. 1.Blasenzentrum WestendBerlinDeutschland

Personalised recommendations