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Determinants of long-term health-related quality of life in adult patients with mild traumatic brain injury

  • Shahrokh Yousefzadeh-Chabok
  • Fatemeh Ramezani Kapourchali
  • Sara RamezaniEmail author
Original Article

Abstract

Purpose

Mild traumatic brain injury (mTBI) usually leads to the appearance of post-concussion symptoms (PCS) which may resolve after a short time. In this study, the mental and physical aspects of quality of life (QoL) were evaluated 6 months after mTBI, and the association of demographic and injury-related factors, post-injury primary executive function and PCS types with the long-term QoL status was investigated.

Methods

123 eligible mTBI patients of initial sampling participated in follow-up phase of this longitudinal study. The demographic, clinical, and para-clinical data of patients were recorded. Paraclinical data comprised brain lesion volume, type and location determined by CT scan. The executive function and primary PCS were examined during the discharge using the verbal fluency task and a checklist, respectively. QoL was measured via SF-36 questionnaire. The collected data were entered into SPSS 22, and analyzed using appropriate statistical tests.

Results

Youngers aged between 18 and 35 years and women had a lower QoL score than others. Primary somatic and cognitive PCS together were associated with poor QoL. There was no significant difference in QoL and executive function scores between the normal and abnormal brain CT groups. However, among people with abnormal CT, those having multifocal lesions including at least an intracranial hemorrhage type such as intra parenchymal hemorrhage or extra-axial bleeding together with other intracranial lesions or skull fracture demonstrated less QoL score in SF-36. A significant correlation was discovered between the scores of the executive function and QoL in mental dimensions of SF-36.

Conclusions

This study emphasizes on the clinical significance of early executive function and PCS examination in mTBI population, as well as optimal management of the victims regardless of the initial brain CT findings, especially in high-risk populations.

Keywords

Executive function Post-concussion symptoms Minor brain trauma Neuroimaging SF-36 

Notes

Acknowledgements

The authors are grateful to the staff of the Neurosurgery and Emergency departments of Poursina hospital, Rasht, Iran and the staff at Guilan Road Trauma Research Center, Poursina General Hospital, Rasht, Iran for their valuable support in data collection.

Compliance with ethical standards

Conflict of interest

The authors mention that there is no conflict of interest in this study.

Ethical approval

Research has been performed in accordance with the Declaration of Helsinki about human subjects that have been approved by the ethical committee of Guilan University of medical sciences. Based on the guidelines regulated in the Declaration of Helsinki, written informed consent was obtained from all subjects. Also authors mention that there is no conflict of interest in this study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Shahrokh Yousefzadeh-Chabok
    • 1
    • 2
  • Fatemeh Ramezani Kapourchali
    • 3
  • Sara Ramezani
    • 1
    • 2
    Email author
  1. 1.Neuroscience Research Center, School of MedicineGuilan University of Medical SciencesRashtIran
  2. 2.Guilan Road Trauma Research CenterGuilan University of Medical SciencesRashtIran
  3. 3.Department of Inflammation and ImmunityLerner Research Institute, Cleveland ClinicClevelandUSA

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