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Can cortisol levels predict the severity of acute whiplash-associated disorders?

  • Daniela Shaked
  • Gad Shaked
  • Gilbert Sebbag
  • David Czeiger
Original Article
  • 19 Downloads

Abstract

Background

The exact underlying mechanism of whiplash-associated disorders still remains obscure. Central sensitization of the brain to painful stimulus and disturbances in the hypothalamic–pituitary–adrenal axis has been suggested to contribute to the development of whiplash-associated disorders. Although cortisol is a well-known factor in the acute stress response and its effects on chronic pain sensation were studied, information is lacking regarding the relation between acute phase cortisol concentrations and the intensity of whiplash-associated disorders. The aim of this prospective observational study was to investigate the relationship between acute serum cortisol concentrations and the severity of whiplash-associated disorders.

Methods

55 patients enrolled in the study and they answered a pertinent questionnaire. A blood sample was drawn to determine serum cortisol concentration.

Results

The mean cortisol concentration of the whiplash-associated disorder score 2–3 patients was significantly lower compared to the whiplash-associated disorder score 1 patients, 9.5 ± 6.9 vs. 13.22 ± 8.3 µg% (p = 0.02). The mean cortisol concentrations increased significantly from mild through moderate to serious grade of severity of accident as perceived by the patient, 9.64 ± 4.82, 11.59 ± 6.85, 17.39 ± 12.1 µg% (p = 0.02).

Conclusions

The study supports the possibility that cortisol plays a role in the development of whiplash-associated disorders. Low or relatively low cortisol concentrations might be associated with more severe forms of the disorder.

Keywords

Neck injury Whiplash Cortisol Stress 

Notes

Compliance with ethical standards

Conflict of interest

All authors declare to have no conflict of interest in this research.

Ethical approval

The study was approved by the local Institutional Review Board committee (SOR-0237-13).

Informed consent

All patients enrolled into the study signed a consent form.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Daniela Shaked
    • 1
  • Gad Shaked
    • 2
  • Gilbert Sebbag
    • 2
  • David Czeiger
    • 2
  1. 1.Physical Therapy Department, Recanati School for Community Health Professions, Faculty of Health SciencesBen-Gurion UniversityBeer ShevaIsrael
  2. 2.Department of General Surgery and Trauma UnitSoroka University Medical Center, Ben-Gurion UniversityBeer ShevaIsrael

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