Interleukin-17 as a predictor of sepsis in polytrauma patients: a prospective cohort study
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Sepsis is one of the most serious complications after major trauma, and may be associated with increased mortality. We sought to determine whether there is an association between serum levels of interleukin-17 (IL-17) at the time of admission to the intensive care unit (ICU) and the development of sepsis. We evaluated 100 adult patients with major trauma admitted to the surgical ICU over a 6-month period. Serum levels of IL-17, IL-6, and TNF-α were determined by enzyme-linked immunosorbent assays (ELISA). The IL-17 rs1974226 genotype was determined by real-time PCR. In both non-adjusted and adjusted analyses, IL-17 was the only biomarker significantly associated with sepsis [median serum IL-17 of 72 pg/mL in sepsis versus 37 pg/mL in those without sepsis, P = 0.0001; adjusted odds ratio (OR) 3.2, P = 0.02]. No significant association was found among IL-17 rs1974226 genotypes and related serum cytokine levels. These data suggest that elevated serum IL-17 may increase the susceptibility for septic complications in polytrauma patients and so could be a useful biomarker for trauma patient management.
KeywordsIL-17 Trauma Sepsis Polymorphism IL-6 TNF
Compliance with ethical standards
Conflict of interest
Mai Ahmed Ali Elsayed, Emily Samir Mikhael, Amr Abdelkader, Lamia Mansour, Riham El Essawy, Riham El Sayed, Akram Eladawy, and Ahmed Mukhtar declare that they have no conflict of interest.
This research includes human participants.
Approval of the research ethics committee of Cairo University and an informed consent were obtained from the patients’ next of kin.
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