Advertisement

Non-traumatic hemorrhage is controlled with REBOA in acute phase then mortality increases gradually by non-hemorrhagic causes: DIRECT-IABO registry in Japan

  • Y. Matsumura
  • J. Matsumoto
  • K. Idoguchi
  • H. Kondo
  • T. Ishida
  • Y. Kon
  • K. Tomita
  • K. Ishida
  • T. Hirose
  • K. Umakoshi
  • T. Funabiki
  • DIRECT-IABO investigators
Original Article

Abstract

Purpose

Resuscitative endovascular balloon occlusion of the aorta (REBOA) is now a feasible and less invasive resuscitation procedure. This study aimed to compare the clinical course of trauma and non-trauma patients undergoing REBOA.

Methods

Patient demographics, etiology, bleeding sites, hemodynamic response, length of critical care, and cause of death were recorded. Characteristics and outcomes were compared between non-trauma and trauma patients. Kaplan–Meier survival analysis was then conducted.

Results

Between August 2011 and December 2015, 142 (36 non-trauma; 106 trauma) cases were analyzed. Non-traumatic etiologies included gastrointestinal bleeding, obstetrics and gynecology-derived events, visceral aneurysm, abdominal aortic aneurysm, and post-abdominal surgery. The abdomen was a common bleeding site (69%), followed by the pelvis or extra-pelvic retroperitoneum. None of the non-trauma patients had multiple bleeding sites, whereas 45% of trauma patients did (P < 0.001). No non-trauma patients required resuscitative thoracotomy compared with 28% of the trauma patients (P < 0.001). Non-trauma patients presented a lower 24-h mortality than trauma patients (19 vs. 51%, P = 0.001). The non-trauma cases demonstrated a gradual but prolonged increased mortality, whereas survival in trauma cases rapidly declined (P = 0.009) with similar hospital mortality (68 vs. 64%). Non-trauma patients who survived for 24 h had 0 ventilator-free days and 0 ICU-free days vs. a median of 19 and 12, respectively, for trauma patients (P = 0.33 and 0.39, respectively). Non-hemorrhagic death was more common in non-trauma vs. trauma patients (83 vs. 33%, P < 0.001).

Conclusions

Non-traumatic hemorrhagic shock often resulted from a single bleeding site, and resulted in better 24-h survival than traumatic hemorrhage among Japanese patients who underwent REBOA. However, hospital mortality increased steadily in non-trauma patients affected by non-hemorrhagic causes after a longer period of critical care.

Keywords

Resuscitative endovascular occlusion of the aorta (REBOA) Trauma Non-trauma Critical care Hemorrhagic shock 

Notes

Acknowledgements

We thank all the members and investigators of DIRECT-IABO. Osaka City University Hospital (Naohiro Hagawa MD); Ohta Nishinouchi Hospital (Tokiya Ishida MD); National Hospital Organization Osaka National Hospital (Kenichiro Ishida MD); Nippon Medical School Musashikosugi Hospital (Eiji Yamamura MD); Ehime University Hospital (Kensuke Umakoshi MD); Saga University Hospital (Kosuke Chiris Yamada MD); Tokyobay Urayasu-Ichikawa Medical Center (Yosuke Homma MD); Osaka University Hospital (Tomoya Hirose MD); Kouseiren Takaoka Hospital (Mahiro Fujii MD); Asahi General Hospital (Chikao Ito MD); Teikyo University Hospital (Takahiro Yamamoto MD); Saiseikai Yokohamashi Tobu Hospital (Tomohiko Orita MD); St. Marianna University Hospital (Junichi Matsumoto MD); Senshu Trauma and Critical Care Medical Center (Koji Idoguchi MD); Hachinohe City Hospital (Yuri Kon MD); Chiba University Hospital (Keisuke Tomita MD); Yokohama Rosai Hospital (Takafumi Shinjo MD); Toho University Omori Medical Center (Yukitoshi Toyoda MD).

Author contributions

YM contributed to study conception and design, analysis and interpretation of data, statistical analysis, and drafting of the manuscript. JM, KI, HK, and TF contributed to the critical revision of the manuscript for important intellectual content and provided intellectual input to the research and manuscript. TI, YK, KT, KI, TH, and KU contributed to data acquisition and provided intellectual input to the research and manuscript. All authors read and approved the manuscript.

Compliance with ethical standards

Conflict of interest

Yosuke Matsumura is a member of clinical advisory board member of Tokai Medical Products. None of the other authors have any conflicts of interest to declare.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Ethical approval

All participating hospitals obtained individual local Institutional Review Board approval prior to registration of patient data. Individual consent was waived to register the observational data and was approved by the JAST Ethical Committee.

Supplementary material

68_2017_829_MOESM1_ESM.docx (22 kb)
Supplementary material 1 (DOCX 22 kb)

References

  1. 1.
    Tien HC, Spencer F, Tremblay LN, Rizoli SB, Brenneman FD. Preventable deaths from hemorrhage at a level I Canadian trauma center. J Trauma. 2007;62(1):142–6. doi: 10.1097/01.ta.0000251558.38388.47.CrossRefPubMedGoogle Scholar
  2. 2.
    Sanddal TL, Esposito TJ, Whitney JR, Hartford D, Taillac PP, Mann NC, et al. Analysis of preventable trauma deaths and opportunities for trauma care improvement in utah. J Trauma. 2011;70(4):970–7. doi: 10.1097/TA.0b013e3181fec9ba.CrossRefPubMedGoogle Scholar
  3. 3.
    Nakahara S, Katanoda K, Ichikawa M. Onset of a declining trend in fatal motor vehicle crashes involving drunk-driving in Japan. J Epidemiol. 2013;23(3):195–204.CrossRefPubMedGoogle Scholar
  4. 4.
    Kaimila B, Yamashina H, Arai A, Tamashiro H. Road traffic crashes and fatalities in Japan 2000–2010 with special reference to the elderly road user. Traffic Inj Prev. 2013;14(8):777–81. doi: 10.1080/15389588.2013.774085.CrossRefPubMedGoogle Scholar
  5. 5.
    Stannard A, Eliason JL, Rasmussen TE. Resuscitative endovascular balloon occlusion of the aorta (REBOA) as an adjunct for hemorrhagic shock. J Trauma. 2011;71(6):1869–72. doi: 10.1097/TA.0b013e31823fe90c.PubMedGoogle Scholar
  6. 6.
    Brenner ML, Moore LJ, DuBose JJ, Tyson GH, McNutt MK, Albarado RP, et al. A clinical series of resuscitative endovascular balloon occlusion of the aorta for hemorrhage control and resuscitation. J Trauma Acute Care Surg. 2013;75(3):506–11. doi: 10.1097/TA.0b013e31829e5416.CrossRefPubMedGoogle Scholar
  7. 7.
    Saito N, Matsumoto H, Yagi T, Hara Y, Hayashida K, Motomura T, et al. Evaluation of the safety and feasibility of resuscitative endovascular balloon occlusion of the aorta. J Trauma Acute Care Surg. 2015;78(5):897–904. doi: 10.1097/TA.0000000000000614.CrossRefPubMedGoogle Scholar
  8. 8.
    Napolitano LM. Resuscitative endovascular balloon occlusion of the aorta: indications, outcomes, and training. Crit Care Clin. 2017;33(1):55–70. doi: 10.1016/j.ccc.2016.08.011.CrossRefPubMedGoogle Scholar
  9. 9.
    Moore LJ, Brenner M, Kozar RA, Pasley J, Wade CE, Baraniuk MS, et al. Implementation of resuscitative endovascular balloon occlusion of the aorta as an alternative to resuscitative thoracotomy for noncompressible truncal hemorrhage. J Trauma Acute Care Surg. 2015;79(4):523–32. doi: 10.1097/TA.0000000000000809.CrossRefPubMedGoogle Scholar
  10. 10.
    Philipsen TE, Hendriks JM, Lauwers P, Voormolen M, d’Archambeau O, Schwagten V, et al. The use of rapid endovascular balloon occlusion in unstable patients with ruptured abdominal aortic aneurysm. Innovations (Phila). 2009;4(2):74–9. doi: 10.1097/IMI.0b013e3181a00bc9.CrossRefPubMedGoogle Scholar
  11. 11.
    Zhang L, Gong Q, Xiao H, Tu C, Liu J. Control of blood loss during sacral surgery by aortic balloon occlusion. Anesth Analg. 2007;105(3):700–3. doi: 10.1213/01.ane.0000278135.85206.4e.CrossRefPubMedGoogle Scholar
  12. 12.
    Soda H, Kainuma O, Yamamoto H, Nagata M, Takiguchi N, Ikeda A, et al. Giant intrapelvic solitary fibrous tumor arising from mesorectum. Clin J Gastroenterol. 2010;3(3):136–9. doi: 10.1007/s12328-010-0146-0.CrossRefPubMedGoogle Scholar
  13. 13.
    Masamoto H, Uehara H, Gibo M, Okubo E, Sakumoto K, Aoki Y. Elective use of aortic balloon occlusion in cesarean hysterectomy for placenta previa percreta. Gynecol Obstet Invest. 2009;67(2):92–5. doi: 10.1159/000164685.CrossRefPubMedGoogle Scholar
  14. 14.
    Mayer D, Aeschbacher S, Pfammatter T, Veith FJ, Norgren L, Magnuson A, et al. Complete replacement of open repair for ruptured abdominal aortic aneurysms by endovascular aneurysm repair: a two-center 14-year experience. Ann Surg. 2012;256(5):688–95. doi: 10.1097/SLA.0b013e318271cebd (discussion 95–6).CrossRefPubMedGoogle Scholar
  15. 15.
    Teeter WA, Matsumoto J, Idoguchi K, Kon Y, Orita T, Funabiki T, et al. Smaller introducer sheaths for REBOA may be associated with fewer complications. J Trauma Acute Care Surg. 2016;81(6):1039–45. doi: 10.1097/TA.0000000000001143.CrossRefPubMedGoogle Scholar
  16. 16.
    Hörer TM, Cajander P, Jans A, Nilsson KF. A case of partial aortic balloon occlusion in an unstable multi-trauma patient. Trauma. 2016;18(2):150–4. doi: 10.1177/1460408615624727.CrossRefGoogle Scholar
  17. 17.
    Matsumura Y, Matsumoto J, Kondo H, Idoguchi K, Funabiki T, investigators D-I. Partial occlusion, conversion from thoracotomy, undelayed but shorter occlusion: resuscitative endovascular balloon occlusion of the aorta strategy in Japan. Eur J Emerg Med. 2017;. doi: 10.1097/MEJ.0000000000000466.PubMedGoogle Scholar
  18. 18.
    DuBose JJ. How I do it: partial resuscitative endovascular balloon occlusion of the aorta (P-REBOA). J Trauma Acute Care Surg. 2017;. doi: 10.1097/TA.0000000000001462.Google Scholar
  19. 19.
    Morrison JJ, DuBose JJ, Reva VA, Matsumoto J, Matsumura Y, Falkenberg M, et al. Top Stent. http://www.jevtmcom/top-stent/. 2017.
  20. 20.
    DuBose JJ, Scalea TM, Brenner M, Skiada D, Inaba K, Cannon J, et al. The AAST prospective Aortic Occlusion for Resuscitation in Trauma and Acute Care Surgery (AORTA) registry: data on contemporary utilization and outcomes of aortic occlusion and resuscitative balloon occlusion of the aorta (REBOA). J Trauma Acute Care Surg. 2016;81(3):409–19. doi: 10.1097/TA.0000000000001079.CrossRefPubMedGoogle Scholar
  21. 21.
    Ogura T, Lefor AT, Nakano M, Izawa Y, Morita H. Nonoperative management of hemodynamically unstable abdominal trauma patients with angioembolization and resuscitative endovascular balloon occlusion of the aorta. J Trauma Acute Care Surg. 2015;78(1):132–5. doi: 10.1097/TA.0000000000000473.CrossRefPubMedGoogle Scholar
  22. 22.
    Matsuda H, Tanaka Y, Hino Y, Matsukawa R, Ozaki N, Okada K, et al. Transbrachial arterial insertion of aortic occlusion balloon catheter in patients with shock from ruptured abdominal aortic aneurysm. J Vasc Surg. 2003;38(6):1293–6. doi: 10.1016/S0741.CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Y. Matsumura
    • 1
    • 7
  • J. Matsumoto
    • 2
  • K. Idoguchi
    • 3
  • H. Kondo
    • 4
  • T. Ishida
    • 5
  • Y. Kon
    • 6
  • K. Tomita
    • 7
  • K. Ishida
    • 8
  • T. Hirose
    • 9
  • K. Umakoshi
    • 10
  • T. Funabiki
    • 11
  • DIRECT-IABO investigators
  1. 1.R Adams Cowley Shock Trauma CenterUniversity of MarylandBaltimoreUSA
  2. 2.Department of Emergency and Critical Care MedicineSt. Marianna University School of MedicineKawasakiJapan
  3. 3.Senshu Trauma and Critical Care CenterRinku General Medical CenterIzumisanoJapan
  4. 4.Department of RadiologyTeikyo University School of MedicineItabashiJapan
  5. 5.Emergency and Critical Care CenterOhta Nishinouchi HospitalKoriyamaJapan
  6. 6.Emergency and Critical Care CenterHachinohe City HospitalHachinoheJapan
  7. 7.Department of Emergency and Critical Care MedicineChiba University Graduate School of MedicineChibaJapan
  8. 8.Department of Acute Medicine and Critical Care Medical CenterNational Hospital Organization, Osaka National HospitalOsakaJapan
  9. 9.Department of Traumatology and Acute Critical MedicineOsaka University Graduate School of MedicineSuitaJapan
  10. 10.Department of Emergency and Critical Care MedicineEhime University Graduate School of MedicineMatsuyamaJapan
  11. 11.Emergency and Critical Care CenterSaiseikai Yokohamashi Tobu HospitalYokohamaJapan

Personalised recommendations