EGFR-Inhibition bei NSCLC-Tumorzelllinien
Einfluss auf Zellzyklus und Tumorkontrolle
Literatur kommentiert
First Online:
- 95 Downloads
EGFR inhibition in NSCLC tumor cell lines
Influence on cell cycle and tumor control
Notes
Interessenkonflikt
U.S. Gaipl gibt an, dass kein Interessenkonflikt besteht.
Literatur
- 1.Bonner JA, Harari PM, Giralt J, Cohen RB, Jones CU, Sur RK, Raben D, Baselga J, Spencer SA, Zhu J, Youssoufian H, Rowinsky EK, Ang KK (2010) Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5‑year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol 11(1):21–28. doi:10.1016/s1470-2045(09)70311-0CrossRefPubMedGoogle Scholar
- 2.Giralt J, Trigo J, Nuyts S, Ozsahin M, Skladowski K, Hatoum G, Daisne JF, Yunes Ancona AC, Cmelak A, Mesia R, Zhang A, Oliner KS, VanderWalde A (2015) Panitumumab plus radiotherapy versus chemoradiotherapy in patients with unresected, locally advanced squamous-cell carcinoma of the head and neck (CONCERT-2): a randomised, controlled, open-label phase 2 trial. Lancet Oncol 16(2):221–232. doi:10.1016/s1470-2045(14)71200-8CrossRefPubMedGoogle Scholar
- 3.Hotta K, Sasaki J, Saeki S, Takigawa N, Katsui K, Takayama K, Nogami N, Shioyama Y, Bessho A, Kishimoto J, Tanimoto M, Kiura K, Ichinose Y (2015) Gefitinib combined with standard Chemoradiotherapy in EGFR-mutant locally advanced non-small-cell lung cancer: the LOGIK0902/OLCSG0905 intergroup study protocol. Clin Lung Cancer. doi:10.1016/j.cllc.2015.08.004PubMedGoogle Scholar
- 4.Rodel F, Frey B, Multhoff G, Gaipl U (2015) Contribution of the immune system to bystander and non-targeted effects of ionizing radiation. Cancer Lett 356(1):105–113. doi:10.1016/j.canlet.2013.09.015CrossRefPubMedGoogle Scholar
- 5.Tang Y, Fang W, Zhang Y, Hong S, Kang S, Yan Y, Chen N, Zhan J, He X, Qin T, Li G, Tang W, Peng P, Zhang L (2015) The association between PD-L1 and EGFR status and the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs. Oncotarget 6(16):14209–14219CrossRefPubMedPubMedCentralGoogle Scholar
- 6.Crusz SM, Balkwill FR (2015) Inflammation and cancer: advances and new agents. Nat Rev Clin Oncol 12(10):584–596. doi:10.1038/nrclinonc.2015.105CrossRefPubMedGoogle Scholar
- 7.Troiani T, Zappavigna S, Martinelli E, Addeo SR, Stiuso P, Ciardiello F, Caraglia M (2013) Optimizing treatment of metastatic colorectal cancer patients with anti-EGFR antibodies: overcoming the mechanisms of cancer cell resistance. Expert Opin Biol Ther 13(2):241–255. doi:10.1517/14712598.2012.756469CrossRefPubMedGoogle Scholar
- 8.Jones KR, Elmore LW, Jackson-Cook C, Demasters G, Povirk LF, Holt SE, Gewirtz DA (2005) p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells. Int J Radiat Biol 81(6):445–458CrossRefPubMedGoogle Scholar
- 9.Lauber K, Ernst A, Orth M, Herrmann M, Belka C (2012) Dying cell clearance and its impact on the outcome of tumor radiotherapy. Front Oncol 2:116. doi:10.3389/fonc.2012.00116CrossRefPubMedPubMedCentralGoogle Scholar
Copyright information
© Springer-Verlag Berlin Heidelberg 2016