Strahlentherapie und Onkologie

, Volume 190, Issue 10, pp 872–881 | Cite as

Stereotactic body radiotherapy for liver tumors

Principles and practical guidelines of the DEGRO Working Group on Stereotactic Radiotherapy
  • Florian Sterzing
  • Thomas B. Brunner
  • Iris Ernst
  • Wolfgang W. Baus
  • Burkhard Greve
  • Klaus Herfarth
  • Matthias Guckenberger
Original article



This report of the Working Group on Stereotactic Radiotherapy of the German Society of Radiation Oncology (DEGRO) aims to provide a practical guideline for safe and effective stereotactic body radiotherapy (SBRT) of liver tumors.


The literature on the clinical evidence of SBRT for both primary liver tumors and liver metastases was reviewed and analyzed focusing on both physical requirements and special biological characteristics.


Recommendations were developed for patient selection, imaging, planning, treatment delivery, motion management, dose reporting, and follow-up. Radiation dose constraints to critical organs at risk are provided.


SBRT is a well-established treatment option for primary and secondary liver tumors associated with low morbidity.


Liver SBRT Radiosurgery Focal liver irradiation Liver metastases Hepatocellular carcinoma 

Stereotaktische Strahlentherapie von Lebertumorenn

Grundlegende und praktische Leitlinien der DEGRO Arbeitsgruppe Stereotaxie



Die Arbeitsgruppe Stereotaxie der Deutschen Gesellschaft für Radioonkologie (DEGRO) legt hier eine Empfehlung zur sicheren und effektiven Durchführung der SBRT von Lebertumoren vor.


Eine Literaturrecherche zur Untersuchung der Evidenz der SBRT sowohl für primäre Lebertumore als auch für Lebermetastasen wurde durchgeführt. Auf dieser Basis werden Empfehlungen für technisch-physikalische Voraussetzungen wie auch für die tägliche Praxis der Leber-SBRT gegeben. Weiterhin werden radiobiologische Besonderheiten dieses Verfahrens dargestellt.


Praktische Vorgaben werden für Patientenselektion, Bildgebung, Planung, Applikation, Bewegungsmanagement, Dosisdokumentation und Follow-up gegeben. Dosisempfehlungen für die kritischen Risikoorgane werden dargestellt.


Die SBRT stellt eine etablierte Behandlungsmethode für primäre und sekundäre Lebertumore dar und ist mit niedriger Morbidität assoziiert.


Leber-SBRT Radiochirurgie Lokale Leberbestrahlung Leber-metastasen Hepatozelluläres Karzinom 


Compliance with ethical guidelines

Conflict of interest

F. Sterzing, T. B. Brunner, I. Ernst, W. W. Baus, B. Greve, K. Herfarth, and M. Guckenberger state that there are no conflicts of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Florian Sterzing
    • 1
    • 2
  • Thomas B. Brunner
    • 3
  • Iris Ernst
    • 4
  • Wolfgang W. Baus
    • 5
  • Burkhard Greve
    • 4
  • Klaus Herfarth
    • 2
  • Matthias Guckenberger
    • 6
  1. 1.Klinische Kooperationseinheit StrahlentherapieDeutsches Krebsforschungszentrum (dkfz)HeidelbergGermany
  2. 2.Abteilung für Radioonkologie und StrahlentherapieRadiologische UniversitätsklinikHeidelbergGermany
  3. 3.Klinik für Strahlenheilkunde, Radiologische KlinikUniversitätsklinikum FreiburgFreiburgGermany
  4. 4.Klinik für Strahlentherapie – RadioonkologieUniversitätsklinikum MünsterMünsterGermany
  5. 5.Klinik und Poliklinik für StrahlentherapieUniversitätsklinikum KölnKölnGermany
  6. 6.Klinik für Radio-OnkologieUniversitätsSpital ZürichZürichSwitzerland

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