Intraoperative Teilbrustbestrahlung mit Elektronen versus konventionelle externe Ganzbrustbrustbestrahlung beim frühen Mammakarzinom

Ergebnisse der ELIOT-Studie
Literatur kommentiert

Partial breast irradiation with intraoperative electrons versus conventional external whole breast irradiation for early breast cancer

Results of the ELIOT trial


  1. 1.
    Alço G, Iğdem SI, Ercan T et al (2010) Coverage of axillary lymph nodes with high tangential fields in breast radiotherapy. Br J Radiol 83:1072–1076PubMedCentralPubMedCrossRefGoogle Scholar
  2. 2.
    Bartelink H, Bourgier C, Elkhuizen P (2012) Has partial breast irradiation by IORT or brachytherapy been prematurely introduced into the clinic? Radiother Oncol 104:139–142PubMedCrossRefGoogle Scholar
  3. 3.
    Bartelink H, Horiot JC, Poortmans PM et al (2007) Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881-10882 trial. J Clin Oncol 25:3259–3265PubMedCrossRefGoogle Scholar
  4. 4.
    Clark M, Collins R, Darby S et al (2005) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15 year survival: an overview of randomised trials. Early Breast Cancer Trialists‘ Collaborative Group (EBCTCG). Lancet 366:2087–2106CrossRefGoogle Scholar
  5. 5.
    Darby S, McGale P, Correa C et al (2011) Early Breast Cancer Trialists‘ Collaborative Group (EBCTCG). Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet 378:1707–1716PubMedCrossRefGoogle Scholar
  6. 6.
    Fastner G, Sedlmayer F, Merz F et al (2013) IORT with electrons as boost strategy during breast conserving therapy in limited stage breast cancer: long term results of an ISIORT pooled analysis. Radiother Oncol 108:279–286PubMedCrossRefGoogle Scholar
  7. 7.
    Polgár C, Fodor J, Major T et al (2007) Breast-conserving treatment with partial or whole breast irradiation for low-risk invasive breast cancer: 5-year results of a randomized trial. Int J Radiat Oncol Biol Phys 69:694–702PubMedCrossRefGoogle Scholar
  8. 8.
    Sautter-Bihl ML, Sedlmayer F, Budach W et al (2012) One life saved by four prevented recurrences? Update of the early breast cancer trialists confirms: postoperative radiotherapy improves survival after breast conserving surgery. Strahlenther Onkol 188:461–463PubMedCrossRefGoogle Scholar
  9. 9.
    Sautter-Bihl ML, Sedlmayer F, Budach W et al (2014) DEGRO practical guidelines: radiotherapy of breast cancer III: radiotherapy of the lymphatic pathways. Strahlenther Onkol (im Druck)Google Scholar
  10. 10.
    Sedlmayer F, Sautter-Bihl ML, Budach W et al (2013) DEGRO practical guidelines: radiotherapy of breast cancer I: radiotherapy following breast conserving therapy for invasive breast cancer. Strahlenther Onkol 189:825–833PubMedCentralPubMedCrossRefGoogle Scholar
  11. 11.
    Veronesi U, Oreccia R, Maisonneuve P et al (2013) Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial. Lancet Oncol 14:1269–1277PubMedCrossRefGoogle Scholar
  12. 12.
    Vaidya JS, Vyas JJ, Chinoy RF et al (1996) Multicentricity of breast cancer: whole-organ analysis and clinical implications. Br J Cancer 74:820–824PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Universitätsklinik für Radiotherapie und RadioonkologieLandeskrankenhaus Salzburg, Paracelsus Medizinische PrivatuniversitätSalzburgÖsterreich
  2. 2.Universitätsklinik für Spezielle Gynäkologie - BrustzentrumLandeskrankenhaus Salzburg, Paracelsus Medizinische PrivatuniversitätSalzburgÖsterreich

Personalised recommendations