Strahlentherapie und Onkologie

, Volume 190, Issue 2, pp 181–185 | Cite as

Radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy for gingival carcinoma

  • Y. Mukai
  • M. Hata
  • K. Mitsudo
  • I. Koike
  • T. Koizumi
  • S. Oguri
  • M. Kioi
  • M. Omura
  • I. Tohnai
  • T. Inoue
Original article



The aim of this study was to review the efficacy and toxicity of radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy in the treatment of gingival carcinoma.

Methods and materials

In all, 34 patients (21 men and 13 women) with squamous cell carcinoma of the gingiva underwent radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy. Treatment consisted of daily external irradiation and concurrent retrograde superselective intra-arterial infusion with cisplatin and docetaxel. A median total dose of 60 Gy in 30 fractions was delivered to tumors.


Of the 34 patients, 29 (85 %) achieved a complete response (CR) and 5 had residual tumors. Of the 29 patients with a CR, 2 had local recurrences and 1 had distant metastasis 1–15 months after treatment. Twenty-six of the 36 patients had survived at a median follow-up time of 36 months (range 12–79 months); 4 died of cancer and 4 died of non-cancer-related causes. At both 3 and 5 years after treatment, the overall survival rates were 79 % and the cause-specific survival rates were 85 %. Osteoradionecrosis of the mandibular bone only developed in 1 patient after treatment.


Radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy was effective and safe in the treatment of gingival carcinoma. This treatment may be a promising curative and organ-preserving treatment option for gingival carcinoma.


Gingival neoplasms Radiation therapy Retrograde superselective intra-arterial chemotherapy Oral cancer Head and neck cancer 

Strahlenbehandlung des Gingivakarzinoms mit gleichzeitiger retrograder, superselektiver intraarterieller Chemotherapie


Hintergrund und Ziel

Das Ziel dieser Studie war die Überprüfung der Effizienz und Toxizität einer Strahlenbehandlung des Gingivakarzinoms mit gleichzeitiger retrograder, superselektiver intraarterieller Chemotherapie.

Patienten und Methoden

Insgesamt 34 Patienten (21 Männer und 13 Frauen) mit Zahnfleischplattenzellkarzinom erhielten eine Strahlenbehandlung mit gleichzeitiger retrograder, superselektiver intraarterieller Chemotherapie. Die Behandlung umfasste eine tägliche externe Bestrahlung mit gleichzeitiger retrograder, superselektiver intraarterieller Infusion von Cisplatin und Docetaxel. Die Tumore wurden mit einer durchschnittlichen Gesamtdosis von 60 Gy in 30 Fraktionen bestrahlt.


Eine komplette Remission (CR) wurde bei 29 der 34 Patienten (85 %) erzielt; 5 Patienten hatten Resttumore. Von den 29 Patienten mit einer CR wiesen 2 Patienten lokale Rezidive und 1 Patient 1–15 Monate nach der Behandlung Fernmetastasen auf. Nach einer durchschnittlichen Beobachtungszeit von 36 Monaten (12–79 Monate) hatten 26 der 36 Patienten überlebt; 4 Patienten verstarben an Krebs und 4 verstarben an anderen, nicht krebsbezogenen Ursachen. Sowohl 3 und 5 Jahre nach der Behandlung betrug die Gesamtüberlebensrate 79 % und die ursachenspezifische Überlebensrate 85 %. Eine Osteoradionekrose des Unterkiefers trat nach der Behandlung bei 1 Patienten auf.


Die Strahlenbehandlung mit gleichzeitiger retrograder, superselektiver intraarterieller Chemotherapie war effektiv und sicher bei der Behandlung des Gingivakarzinoms. Diese Therapie kann eine vielversprechende, heilende und organsparende Behandlungsmöglichkeit für Gingivakarzinome darstellen.


Gingivaneoplasien Strahlentherapie Retrograder superselektiver intraarterielle Chemotherapie Mundkrebs Kopf- und Halskrebs 


Compliance with ethical guidelines

Conflict of interest. Y. Mukai, M. Hata, K. Mitsudo, I. Koike, T. Koizumi, S. Oguri, M. Kioi, M. Omura, I. Tohnai, and T. Inoue state that there is no conflict of interest.

All studies on humans described in the present manuscript were carried out with the approval of the responsible ethics committee and in accordance with national law and the Helsinki Declaration of 1975 (in its current, revised form). Informed consent was obtained from all patients included in studies.


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Copyright information

© Springer Heidelberg Berlin 2013

Authors and Affiliations

  • Y. Mukai
    • 1
  • M. Hata
    • 1
  • K. Mitsudo
    • 2
  • I. Koike
    • 1
  • T. Koizumi
    • 2
  • S. Oguri
    • 2
  • M. Kioi
    • 2
  • M. Omura
    • 3
  • I. Tohnai
    • 2
  • T. Inoue
    • 1
  1. 1.Department of RadiologyYokohama City University Graduate School of MedicineKanazawa-ku, Yokohama, KanagawaJapan
  2. 2.Department of Oral and Maxillofacial SurgeryYokohama City University Graduate School of MedicineYokohama, KanagawaJapan
  3. 3.Department of Radiation OncologyShonankamakura General HospitalKamakura, KanagawaJapan

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