Strahlentherapie und Onkologie

, Volume 188, Supplement 3, pp 299–303 | Cite as

Tumorpathophysiologie

  • L.A. Kunz-Schughart
  • W. Mueller-Klieser
  • P. Vaupel
Originalien

Tumor pathophysiology

Notes

Interessenkonflikt

Der korrespondierende Autor gibt für sich und seine Koautoren an, dass kein Interessenkonflikt besteht.

Literatur

  1. 1.
    Agrawal V, Alpini SE, Stone EM et al (2012) Targeting methionine auxotrophy in cancer: discovery and exploration. Expert Opin Biol Ther 12(1):53–61PubMedCrossRefGoogle Scholar
  2. 2.
    Berridge MV, Herst PM, Tan AS (2010) Metabolic flexibility and cell hierarchy in metastatic cancer. Mitochondrion 10(6):584–588PubMedCrossRefGoogle Scholar
  3. 3.
    Bonuccelli G, Tsirigos A, Whitaker-Menezes D et al (2010) Ketones and lactate „fuel“ tumor growth and metastasis: evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle 9(17):3506–3514PubMedCrossRefGoogle Scholar
  4. 4.
    Borovski T, De Sousa E Melo, Vermeulen L et al (2011) Cancer stem cell niche: the place to be. Cancer Res 71(3):634–639PubMedCrossRefGoogle Scholar
  5. 5.
    Brunner TB, Kunz-Schughart LA, Grosse-Gehling P et al (2012) Cancer stem cells as a predictive factor in radiotherapy. Semin Radiat Oncol 22(2):151–174PubMedCrossRefGoogle Scholar
  6. 6.
    Burness ML, Sipkins DA (2010) The stem cell niche in health and malignancy. Semin Cancer Biol 20(2):107–115PubMedCrossRefGoogle Scholar
  7. 7.
    Delage B, Fennell DA, Nicholson L et al (2010) Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer. Int J Cancer 126(12):2762–2772PubMedGoogle Scholar
  8. 8.
    Fabian C, Koetz L, Favaro E et al (2012) Protein profiles in human ovarian cancer cell lines correspond to their metabolic activity and to metabolic profiles of respective tumor xenografts. FEBS J 279(5):882–891PubMedCrossRefGoogle Scholar
  9. 9.
    Fischer K, Hoffmann P, Voelkl S et al (2007) Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood 109(9):3812–3819PubMedCrossRefGoogle Scholar
  10. 10.
    Goetze K, Walenta S, Ksiazkiewicz M et al (2011) Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release. Int J Oncol 39(2):453–463PubMedGoogle Scholar
  11. 11.
    Gottfried E, Kunz-Schughart LA, Ebner S et al (2006) Tumor-derived lactic acid modulates dendritic cell activation and antigen expression. Blood 107(5):2013–2021PubMedCrossRefGoogle Scholar
  12. 12.
    Hirschhaeuser F, Sattler UG, Mueller-Klieser W (2011) Lactate: a metabolic key player in cancer. Cancer Res 71(22):6921–6925PubMedCrossRefGoogle Scholar
  13. 13.
    Höckel M, Schlenger K, Aral B et al (1996) Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56(19):4509–4515PubMedGoogle Scholar
  14. 14.
    Höckel M, Schlenger K, Knoop C et al (1991) Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements. Cancer Res 51(22):6098–6102PubMedGoogle Scholar
  15. 15.
    Jose C, Bellance N, Rossignol R (2011) Choosing between glycolysis and oxidative phosphorylation: a tumor’s dilemma? Biochim Biophys Acta 1807(6):552–561PubMedCrossRefGoogle Scholar
  16. 16.
    Lathia JD, Heddleston JM, Venere M et al (2011) Deadly teamwork: neural cancer stem cells and the tumor microenvironment. Cell Stem Cell 8(5):482–485PubMedCrossRefGoogle Scholar
  17. 17.
    Mayer A, Höckel M, Vaupel P (2006) Endogenous hypoxia markers in locally advanced cancers of the uterine cervix: reality or wishful thinking? Strahlenther Onkol 182(9):501–510PubMedCrossRefGoogle Scholar
  18. 18.
    Mohyeldin A, Garzon-Muvdi T, Quinones-Hinojosa A (2010) Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell 7(2):150–161PubMedCrossRefGoogle Scholar
  19. 19.
    Nardo G, Favaro E, Curtarello M et al (2011) Glycolytic phenotype and AMP kinase modify the pathologic response of tumor xenografts to VEGF neutralization. Cancer Res 71(12):4214–4225PubMedCrossRefGoogle Scholar
  20. 20.
    Neri D, Supuran CT (2011) Interfering with pH regulation in tumours as a therapeutic strategy. Nat Rev Drug Discov 10(10):767–777PubMedCrossRefGoogle Scholar
  21. 21.
    Porporato PE, Dhup S, Dadhich RK et al (2011) Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review. Front Pharmacol 2:49PubMedCrossRefGoogle Scholar
  22. 22.
    Sattler UG, Meyer SS, Quennet V et al (2010) Glycolytic metabolism and tumour response to fractionated irradiation. Radiother Oncol 94(1):102–109PubMedCrossRefGoogle Scholar
  23. 23.
    Scadden DT (2006) The stem-cell niche as an entity of action. Nature 441(7097):1075–1079PubMedCrossRefGoogle Scholar
  24. 24.
    Smolkova K, Plecita-Hlavata L, Bellance N et al (2011) Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells. Int J Biochem Cell Biol 43(7):950–968PubMedCrossRefGoogle Scholar
  25. 25.
    Vander Heiden MG (2011) Targeting cancer metabolism: a therapeutic window opens. Nat Rev Drug Discov 10(9):671–684CrossRefGoogle Scholar
  26. 26.
    Vaupel P, Höckel M, Mayer A (2007) Detection and characterization of tumor hypoxia using pO2 histography. Antioxid Redox Signal 9(8):1221–1235PubMedCrossRefGoogle Scholar
  27. 27.
    Vaupel P, Mayer A, Höckel M (2006) Oxygenation status of primary and recurrent squamous cell carcinomas of the vulva. Eur J Gynaecol Oncol 27(2):142–146PubMedGoogle Scholar
  28. 28.
    Vaupel P, Schlenger K, Knoop C et al (1991) Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements. Cancer Res 51(12):3316–3322PubMedGoogle Scholar
  29. 29.
    Vynnytska-Myronovska B, Bobak Y, Garbe Y et al (2012) Single amino acid arginine starvation efficiently sensitizes cancer cells to canavanine treatment and irradiation. Int J Cancer 130(9):2164–2175PubMedCrossRefGoogle Scholar
  30. 30.
    Wenner CE (2012) Targeting mitochondria as a therapeutic target in cancer. J Cell Physiol 227(2):450–456PubMedCrossRefGoogle Scholar
  31. 31.
    Zhao Y, Liu H, Riker AI et al (2011) Emerging metabolic targets in cancer therapy. Front Biosci 16:1844–1860PubMedCrossRefGoogle Scholar

Copyright information

© Urban & Vogel 2012

Authors and Affiliations

  • L.A. Kunz-Schughart
    • 1
  • W. Mueller-Klieser
    • 2
  • P. Vaupel
    • 3
  1. 1.OncoRay – Nationales Zentrum für Strahlenforschung in der OnkologieMedizinische Fakultät Carl Gustav Carus, Technische Universität DresdenDresdenDeutschland
  2. 2.Institut für Physiologie und PathophysiologieUniversitätsmedizin der Johannes Gutenberg-Universität MainzMainzDeutschland
  3. 3.Klinik für Strahlentherapie und Radiologische OnkologieKlinikum rechts der Isar, TU MünchenMünchenDeutschland

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