Tumorpathophysiologie
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Tumor pathophysiology
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Interessenkonflikt
Der korrespondierende Autor gibt für sich und seine Koautoren an, dass kein Interessenkonflikt besteht.
Literatur
- 1.Agrawal V, Alpini SE, Stone EM et al (2012) Targeting methionine auxotrophy in cancer: discovery and exploration. Expert Opin Biol Ther 12(1):53–61PubMedCrossRefGoogle Scholar
- 2.Berridge MV, Herst PM, Tan AS (2010) Metabolic flexibility and cell hierarchy in metastatic cancer. Mitochondrion 10(6):584–588PubMedCrossRefGoogle Scholar
- 3.Bonuccelli G, Tsirigos A, Whitaker-Menezes D et al (2010) Ketones and lactate „fuel“ tumor growth and metastasis: evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle 9(17):3506–3514PubMedCrossRefGoogle Scholar
- 4.Borovski T, De Sousa E Melo, Vermeulen L et al (2011) Cancer stem cell niche: the place to be. Cancer Res 71(3):634–639PubMedCrossRefGoogle Scholar
- 5.Brunner TB, Kunz-Schughart LA, Grosse-Gehling P et al (2012) Cancer stem cells as a predictive factor in radiotherapy. Semin Radiat Oncol 22(2):151–174PubMedCrossRefGoogle Scholar
- 6.Burness ML, Sipkins DA (2010) The stem cell niche in health and malignancy. Semin Cancer Biol 20(2):107–115PubMedCrossRefGoogle Scholar
- 7.Delage B, Fennell DA, Nicholson L et al (2010) Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer. Int J Cancer 126(12):2762–2772PubMedGoogle Scholar
- 8.Fabian C, Koetz L, Favaro E et al (2012) Protein profiles in human ovarian cancer cell lines correspond to their metabolic activity and to metabolic profiles of respective tumor xenografts. FEBS J 279(5):882–891PubMedCrossRefGoogle Scholar
- 9.Fischer K, Hoffmann P, Voelkl S et al (2007) Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood 109(9):3812–3819PubMedCrossRefGoogle Scholar
- 10.Goetze K, Walenta S, Ksiazkiewicz M et al (2011) Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release. Int J Oncol 39(2):453–463PubMedGoogle Scholar
- 11.Gottfried E, Kunz-Schughart LA, Ebner S et al (2006) Tumor-derived lactic acid modulates dendritic cell activation and antigen expression. Blood 107(5):2013–2021PubMedCrossRefGoogle Scholar
- 12.Hirschhaeuser F, Sattler UG, Mueller-Klieser W (2011) Lactate: a metabolic key player in cancer. Cancer Res 71(22):6921–6925PubMedCrossRefGoogle Scholar
- 13.Höckel M, Schlenger K, Aral B et al (1996) Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56(19):4509–4515PubMedGoogle Scholar
- 14.Höckel M, Schlenger K, Knoop C et al (1991) Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements. Cancer Res 51(22):6098–6102PubMedGoogle Scholar
- 15.Jose C, Bellance N, Rossignol R (2011) Choosing between glycolysis and oxidative phosphorylation: a tumor’s dilemma? Biochim Biophys Acta 1807(6):552–561PubMedCrossRefGoogle Scholar
- 16.Lathia JD, Heddleston JM, Venere M et al (2011) Deadly teamwork: neural cancer stem cells and the tumor microenvironment. Cell Stem Cell 8(5):482–485PubMedCrossRefGoogle Scholar
- 17.Mayer A, Höckel M, Vaupel P (2006) Endogenous hypoxia markers in locally advanced cancers of the uterine cervix: reality or wishful thinking? Strahlenther Onkol 182(9):501–510PubMedCrossRefGoogle Scholar
- 18.Mohyeldin A, Garzon-Muvdi T, Quinones-Hinojosa A (2010) Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell 7(2):150–161PubMedCrossRefGoogle Scholar
- 19.Nardo G, Favaro E, Curtarello M et al (2011) Glycolytic phenotype and AMP kinase modify the pathologic response of tumor xenografts to VEGF neutralization. Cancer Res 71(12):4214–4225PubMedCrossRefGoogle Scholar
- 20.Neri D, Supuran CT (2011) Interfering with pH regulation in tumours as a therapeutic strategy. Nat Rev Drug Discov 10(10):767–777PubMedCrossRefGoogle Scholar
- 21.Porporato PE, Dhup S, Dadhich RK et al (2011) Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review. Front Pharmacol 2:49PubMedCrossRefGoogle Scholar
- 22.Sattler UG, Meyer SS, Quennet V et al (2010) Glycolytic metabolism and tumour response to fractionated irradiation. Radiother Oncol 94(1):102–109PubMedCrossRefGoogle Scholar
- 23.Scadden DT (2006) The stem-cell niche as an entity of action. Nature 441(7097):1075–1079PubMedCrossRefGoogle Scholar
- 24.Smolkova K, Plecita-Hlavata L, Bellance N et al (2011) Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells. Int J Biochem Cell Biol 43(7):950–968PubMedCrossRefGoogle Scholar
- 25.Vander Heiden MG (2011) Targeting cancer metabolism: a therapeutic window opens. Nat Rev Drug Discov 10(9):671–684CrossRefGoogle Scholar
- 26.Vaupel P, Höckel M, Mayer A (2007) Detection and characterization of tumor hypoxia using pO2 histography. Antioxid Redox Signal 9(8):1221–1235PubMedCrossRefGoogle Scholar
- 27.Vaupel P, Mayer A, Höckel M (2006) Oxygenation status of primary and recurrent squamous cell carcinomas of the vulva. Eur J Gynaecol Oncol 27(2):142–146PubMedGoogle Scholar
- 28.Vaupel P, Schlenger K, Knoop C et al (1991) Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements. Cancer Res 51(12):3316–3322PubMedGoogle Scholar
- 29.Vynnytska-Myronovska B, Bobak Y, Garbe Y et al (2012) Single amino acid arginine starvation efficiently sensitizes cancer cells to canavanine treatment and irradiation. Int J Cancer 130(9):2164–2175PubMedCrossRefGoogle Scholar
- 30.Wenner CE (2012) Targeting mitochondria as a therapeutic target in cancer. J Cell Physiol 227(2):450–456PubMedCrossRefGoogle Scholar
- 31.Zhao Y, Liu H, Riker AI et al (2011) Emerging metabolic targets in cancer therapy. Front Biosci 16:1844–1860PubMedCrossRefGoogle Scholar
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