Fluid resuscitation after severe trauma injury

U-shaped associations between tetrastarch dose and survival time or frequency of acute kidney failure
  • E. Fleischhacker
  • H. Trentzsch
  • D. Kuppinger
  • S. Piltz
  • F. Beyer
  • F. Meigel
  • T. Kammerer
  • M. Rehm
  • W. H. HartlEmail author



Using tetrastarch for fluid resuscitation after a severe trauma injury may increase risks of death and acute kidney injury. The importance of tetrastarch dose, however, is unknown.


A retrospective observational study was performed in two trauma centres using data on type and amount of fluids (balanced crystalloids or tetrastarch) used for pre- and acute in-hospital shock management. We evaluate independent associations between the relative and absolute volumes of tetrastarch and 90-day survival time or the frequency of severe acute kidney failure (AKF).


We studied 271 patients who had sustained a severe blunt trauma injury (average predicted mortality according to the Revised Injury Severity Classification Score (RISC) 15.1 ± 1.4% [mean, standard deviation]), and who had required more than 2 days of intensive care therapy. In all, 75.3% of patients had received tetrastarch with a crystalloid/colloid ratio of 2.93 ± 2.60. The 90-day mortality was 11.1%, and 7.8% of the patients developed severe AKF. After adjusting for confounders, we found a U-shaped, nonlinear association between absolute or relative volumes of tetrastarch and survival time (p = 0.003 and 0.025, respectively). Optimal relative volumes of tetrastarch approximately ranged from 20 to 30% of total fluids. Giving less than about 1000 ml, or more than about 2000 ml tetrastarch was significantly associated with an increased risk of developing severe AKF (p = 0.023).


There was a complex U‑shaped association between the tetrastarch dose and morbidity/mortality of patients after a severe trauma injury. The optimal crystalloid/tetrastarch ratio for acute shock management appears to range from about 2.5 to 4.0.


Tetrastarch Severe trauma injury Mortality Acute kidney failure Cristalloids 

Therapie des Volumenmangelschocks nach Polytrauma

U-förmige Assoziation zwischen Tetrastärke(HES)-Dosis und Überlebenszeit bzw. Häufigkeit eines akuten Nierenversagens



Die Therapie des Volumenmangelschocks nach Polytrauma mittels Tetrastärke (HES; 130/0,38–0,45 oder 0,42) wird angeschuldigt, das Sterberisiko bzw. Risiko eines akuten Nierenversagens zu erhöhen. Inwieweit dabei die Tetrastärkedosis von Bedeutung ist, ist nicht bekannt.


In einer retrospektiven Beobachtungsstudie an 2 Traumazentren wurden Art und Menge von Flüssigkeiten (balancierte Kristalloide und Tetrastärke) erhoben, die zur präklinischen und akuten innerklinischen Therapie des traumainduzierten Kreislaufschocks verabreicht worden waren. Wir untersuchten unabhängige Assoziationen zwischen relativen bzw. absoluten Tetrastärkevolumina und der 90-Tage-Überlebenszeit bzw. der Häufigkeit eines schweren akuten Nierenversagens (ANV).


Ausgewertet wurden 271 Patienten nach schwerem stumpfem Polytrauma (vorhergesagte durchschnittliche Letalität nach dem Revised Injury Severity Classification Score [RISC] 15,1 ± 1,4 % [MW ± SD]), die mehr als 2 Tage intensivmedizinisch hatten versorgt werden müssen. 75,3 % der Patienten hatten Tetrastärke mit einem Kristalloid-Kolloid-Verhältnis von 2,93 ± 2,60 erhalten. Die 90-Tage-Letalität betrug 11,1 % und 7,8 % der Patienten entwickelten ein ANV. Nach Adjustierung an Konfounder zeigte sich eine U‑förmige, nichtlineare Assoziation zwischen absoluten und relativen Tetrastärkevolumina und der Überlebenszeit (p = 0,003 und 0,025). Die besten klinischen Ergebnisse wurden beobachtet, wenn 20–30 % der zugeführten Flüssigkeiten in Form von Tetrastärke verabreicht worden waren. Die Gabe von weniger als 1000 ml oder mehr als 2000 ml Tetrastärke war signifikant mit einem erhöhten Risiko assoziiert, ein ANV zu entwickeln (p = 0,023).


Nach schwerem Polytrauma besteht eine komplexe U‑förmige Assoziation zwischen der Tetrastärkedosis und der Morbidität/Letalität. Das für die akute Schocktherapie optimale Kristalloid-Kolloid-Verhältnis scheint zwischen 2,5 und 4,0 zu liegen.


Tetrastärke Polytrauma Letalität Akutes Nierenversagen Kristalloide 


Author Contribution

W.H. Hartl, E. Fleischhacker, M. Rehm and H. Trentzsch designed the study. D. Kuppinger, F. Meigel, T. Kammerer and F. Beyer acquired the data. W.H. Hartl, M. Rehm, H. Trentzsch and E. Fleischhacker performed the statistical analyses and drafted the manuscript. All authors contributed to interpretation of the data and critical revision of the manuscript.

Compliance with ethical guidelines

Conflict of interest

H. Trentzsch reports personal fees from Akademie der Unfallchirurgie, München, Germany, outside the submitted work. T. Kammerer reports grants from Deutsche Gesellschaft für Berg- und Expeditionsmedizin e. V., Haar, Germany and technical support from Covidien Medtronic Neustadt an der Donau, Germany, outside the submitted work. M. Rehm reports grants from CSL Behring, München, Germany and Fresenius Kabi, Bad Homburg, Germany, outside the submitted work. W. H. Hartl reports personal fees from Fresenius Kabi, Bad Homburg Germany, outside the submitted work. E. Fleischhacker, D. Kuppinger, S. Piltz, F. Beyer and F. Meigel declare that they have no competing interests.

The anonymous retrospective data analysis was approved by the institutional review board of the LMU.

Supplementary material

63_2019_625_MOESM1_ESM.pdf (744 kb)
Detailed discussion of studies evaluating HES dose (table S1), of general outcomes, and of limitations of individual studies/meta-analyses examining the effect of tetrastarch on morbidity and mortality in critically ill patients (tables S2, S3), graphs on the association between tetrastarch and the frequency of an acute kidney failure/the number of transfused PRBC units (figures S1–S6), additional information on general care of trauma patients, and details of the statistical analysis.


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Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2019

Authors and Affiliations

  • E. Fleischhacker
    • 1
  • H. Trentzsch
    • 2
  • D. Kuppinger
    • 3
  • S. Piltz
    • 1
    • 7
  • F. Beyer
    • 3
    • 5
  • F. Meigel
    • 3
    • 4
  • T. Kammerer
    • 6
    • 8
  • M. Rehm
    • 6
  • W. H. Hartl
    • 3
    Email author
  1. 1.Department of General, Trauma and Reconstruction Surgery with Integrated Fracture Liaison Service, University School of Medicine, Grosshadern CampusLudwig-Maximilian UniversityMunichGermany
  2. 2.Institut für Notfallmedizin und Medizinmanagement, Klinikum der Universität MünchenLudwig-Maximilians UniversitätMunichGermany
  3. 3.Department of General, Visceral and Transplantation Surgery, University School of Medicine, Grosshadern CampusLudwig-Maximilian UniversityMunichGermany
  4. 4.Department of GynaecologyMunicipal Hospital TraunsteinTraunsteinGermany
  5. 5.Department of Orthopaedic SurgeryMunicipal Hospital SchrobenhausenSchrobenhausenGermany
  6. 6.Department of Anaesthesiology, University School of Medicine, Grosshadern CampusLudwig-Maximilian UniversityMunichGermany
  7. 7.Department of Orthopaedic SurgeryMunicipal Hospital CoburgCoburgGermany
  8. 8.Department of Anaesthesiology and Pain TherapyCardiac and Diabetes Centre North Rhine-WestphaliaBochumGermany

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