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Blakeʼs Pouch Cysts and Differential Diagnoses in Prenatal and Postnatal MRI

A Pictorial Review
  • Thomas KauEmail author
  • Robert Marterer
  • Raimund Kottke
  • Robert Birnbacher
  • Janos Gellen
  • Eszter Nagy
  • Eugen Boltshauser
Review Article

Abstract

Purpose

The clinical variability of Blakeʼs pouch cysts (BPC) may range from asymptomatic via ataxia to sequelae of decompensated hydrocephalus. On the other hand, Dandy-Walker malformation (DWM) and cerebellar vermis hypoplasia generally correlate with less favorable neurologic development. The aim was to illustrate the potential of prenatal and postnatal neuroimaging to distinguish a BPC or persistent BP from other posterior fossa malformations.

Methods

This pictorial review addresses the inconsistent nomenclature, clinical features, and magnetic resonance imaging (MRI) patterns of BPC and five differential diagnoses. The MRI findings of 11 patients, acquired at up to 3 T in 3 institutions, are demonstrated. Furthermore, the literature was searched for recent improvements in genetic and embryological background knowledge.

Results

Posterior fossa malformations often resemble each other and may even be imitated by sequelae of hemorrhagic, ischemic or infectious disruptions, i.e. congenital anomalies of morphology despite normal developmental potential. Hydrocephalus is a typical, albeit not always congenital finding in BPC. It is frequently associated with cerebellar disruptions and DWM; however, it is also a rare complication of posterior fossa arachnoid cysts. A moderately elevated vermis needs follow-up to confirm persistent BP versus vermian hypoplasia or DWM. The fetal cerebellar tail, previously assumed to be specific for DWM, may be imitated in cases of persistent BP.

Conclusion

The accurate diagnosis of isolated BPC is not always straightforward, which is especially critical in the context of fetomaternal medicine. A detailed description of posterior fossa malformations is to be preferred over unspecific terminology.

Keywords

Arachnoid cyst Mega cisterna magna Cerebellar hypoplasia Dandy-Walker malformation Cerebellar disruption 

Notes

Compliance with ethical guidelines

Conflict of interest

T. Kau, R. Marterer, R. Kottke, R. Birnbacher, J. Gellen, E. Nagy and E. Boltshauser declare that they have no competing interests.

Ethical standards

All investigations described in this manuscript were carried out with the approval of the responsible ethics committee and in accordance with national law and the Helsinki Declaration of 1975 (in its current revised form). Informed consent was obtained from patients if identifiable from images or other information within the manuscript. In the case of underage patients informed consent was obtained from the legal representatives.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Institute of RadiologyVillach General HospitalVillachAustria
  2. 2.Division of Pediatric Radiology, Department of RadiologyMedical University of GrazGrazAustria
  3. 3.Section of Neuroradiology, Department of Diagnostic Imaging and InterventionUniversity Children’s Hospital ZurichZurichSwitzerland
  4. 4.Department of Pediatrics and Adolescent MedicineVillach General HospitalVillachAustria
  5. 5.Division of Obstetrics and Maternal Fetal Medicine, Department of Gynecology and ObstetricsMedical University of GrazGrazAustria
  6. 6.Department of Gynecology and ObstetricsVillach General HospitalVillachAustria
  7. 7.Department of Pediatric NeurologyUniversity Children’s Hospital ZurichZurichSwitzerland

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