Clinical Neuroradiology

, Volume 26, Issue 3, pp 317–323 | Cite as

Is the Susceptibility Vessel Sign on 3-Tesla Magnetic Resonance T2*-Weighted Imaging a Useful Tool to Predict Recanalization in Intravenous Tissue Plasminogen Activator?

  • N. Yamamoto
  • J. Satomi
  • M. Harada
  • Y. Izumi
  • S. Nagahiro
  • R. Kaji
Original Article


The aim of this study was to investigate the independent factors associated with the absence of recanalization approximately 24 h after intravenous administration of tissue-type plasminogen activator (IV TPA). The previous studies have been conducted using 1.5-Tesla (T) magnetic resonance imaging (MRI). We studied whether the characteristics of 3-T MRI findings were useful to predict outcome and recanalization after IV tPA. Patients with internal carotid artery (ICA) or middle cerebral artery (MCA) (horizontal portion, M1; Sylvian portion, M2) occlusion and treated by IV tPA were enrolled. We studied whether the presence of susceptibility vessel sign (SVS) at M1 and low clot burden score on T2*-weighted imaging (T2*-CBS) on 3-T MRI were associated with the absence of recanalization. A total of 49 patients were enrolled (27 men; mean age, 73.9 years). MR angiography obtained approximately 24 h after IV tPA revealed recanalization in 21 (42.9 %) patients. Independent factors associated with the absence of recanalization included ICA or proximal M1 occlusion (odds ratio, 69.6; 95 % confidence interval, 5.05–958.8, p = 0.002). In this study, an independent factor associated with the absence of recanalization may be proximal occlusion of the cerebral arteries rather than SVS in the MCA or low T2*-CBS on 3-T MRI.


3-Tesla MRI T2*-WI tPA Recanalization 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • N. Yamamoto
    • 1
  • J. Satomi
    • 2
  • M. Harada
    • 3
  • Y. Izumi
    • 1
  • S. Nagahiro
    • 2
  • R. Kaji
    • 1
  1. 1.Department of Clinical Neurosciences, Institute of Health BiosciencesThe University of Tokushima Graduate SchoolTokushimaJapan
  2. 2.Department of Neurosurgery, Institute of Health BiosciencesTokushima UniversityTokushimaJapan
  3. 3.Department of Radiology, Institute of Health BiosciencesTokushima UniversityTokushimaJapan

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