Pipeline Embolization Device for Intracranial Aneurysm: A Systematic Review
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The pipeline embolization device (PED) is a new endovascular stent designed for the treatment of challenging intracranial aneurysms (IAs). Its use has been extended to nonruptured and ruptured IAs of a variety of configurations and etiologies in both the anterior and posterior circulations.
We conducted a systematic review of ten eligible reports on its clinical efficacy and safety.
There were 414 patients with 448 IAs. The majority of the IAs were large (40.2 %), saccular or blister-like (78.3 %), and were located mostly in the anterior circulation (83.5 %). The regimens of antiplatelet therapy varied greatly between and within studies. The mean number of the PED used was 2.0 per IA. Deployment was successful in around 95 % of procedures. Aneurysm obliteration was achieved in 82.9 % of IAs at 6-month. The overall incidences of periprocedural intracranial vascular complication rate and mortality rate were 6.3 and 1.5 %, respectively.
The PED is a safe and effective treatment for nonruptured IAs. Its use in the context of acute subarachnoid hemorrhage (SAH) should be cautioned. Its main limitations include the need for prolonged antiplatelet therapy, as well as the potential risks of IA rupture and non-IA-related intracerebral hemorrhages (ICH). Future studies should aim at identifying factors that predispose to incomplete obliteration, delayed rupture, and thromboembolic complications.
KeywordsCerebral aneurysm Endovascular treatment Flow diverter Pipeline embolization device
Endovascular treatment (EVT) has significantly changed the treatment paradigm of intracranial aneurysms (IAs). Endosaccular embolization with or without device assistance is now a widely adopted treatment modality [1, 2]. However, a subgroup of lesions, including fusiform , wide-necked , and large-to-giant aneurysms , continues to present with major challenges. Many of these aneurysms have configurations that are unsuitable or unsafe for embolization and/or conventional stenting. Recently, an alternative approach of endoluminal treatment has been developed for these lesions . It involves the use of flow diverters that can disrupt the pulsatile blood flow within an aneurysm sac to the point of stagnation and thrombosis while maintaining flow in the parent artery and side branches. These devices may also facilitate neointimal regrowth and remodeling of the arterial wall. The initial clinical experiences were promising [7, 8, 9].
The pipeline embolization device (PED; Covidien Vascular Therapies, Mansfield, MA, USA) is one of the commercially available flow diverters . It is a microcatheter-delivered, self-expanding, cylindrical stent composed of a mesh of 48 individual cobalt chromium and platinum strands. Initially, approved for the treatment of IAs situated between the petrous and the superior hypophyseal segments of the internal carotid artery, its use has now been extended to lesions of various configurations and etiologies in both the anterior and posterior circulations. We present here a systematic literature review on the applications, safety, and clinical efficacy of this therapy.
The MEDLINE database was searched for all related articles published in the English language using the following keywords: “aneurysm”, “pipeline embolization device”, and “flow diverters”. These keywords were queried individually or in association. Abstracts were screened for eligibility, and the reference lists of eligible articles were searched for other related studies including on-line documents. The date of the last search was March 21, 2012. We included studies that described the clinical and angiographic outcomes of the PED being used alone or in combination with other modalities. Only reports that consisted of five subjects or more were included. Reports with fewer than five subjects were referred to in the “Discussion” when appropriate.
Data Collection and Analysis
The selection of articles and the evaluation of study qualities were performed independently by two authors (Gilberto Ka Kit Leung and Anderson Chun On Tsang). There was no disagreement. The system classification proposed by Cook et al.  was used to analyze the level of evidence. Data extracted from the eligible studies included the following: characteristics of the IAs (morphology, size, location, clinical presentation, recent rupture, and previous treatment), treatment procedure (antiplatelet and anticoagulating therapies, technical problems during deployment, the number of PEDs used, and adjuvant coiling), symptomatic procedure-related complication and mortality, aneurysm obliteration and recanalization, in-stent stenosis and migration, as well as functional and symptomatic outcomes. We also studied IAs that had received previous stenting as a subgroup. The procedure for the deployment of the PED was standardized and would not be further elaborated here.
Description of Studies
There were ten eligible articles, including seven prospective single-arm cohort studies [9, 12, 13, 14, 15, 16, 17], two retrospective uncontrolled case series [18, 19], and one ongoing randomized controlled open-label trial . All completed studies were classified as Level V (“data from anecdotal case series”). Some of the subjects from two eligible studies were also involved in the PED for the Intracranial Treatment of Aneurysms (PITA) trial . The latter was an international multicenter study on 31 subjects from four centers. Six of the 63 IAs reported by Lylyk et al. , and eight of the 19 by Szikora et al.  were included in the PITA report. However, the available information did not enable us to separate out these 14 overlapping subjects. We therefore conducted the review based on the total number of IAs reported instead of the actual number of IAs treated. The PipelineTM for Uncoilable or Failed Aneurysms Study (PUFS) , and the Complete Occlusion of Coilable Aneurysms (COCOA) Clinical Study  were conducted under an approved investigational device exemptions (IDE) application of the Food and Drug Administration (FDA), and were available as on-line reports.
We have excluded the report by Deutschmann et al.  in which all 12 patients were already included in the PITA report. The report by Puffer et al.  only studied specifically the patency of the ophthalmic artery after treatment and was also excluded. As mentioned, we have excluded reports that described fewer than five subjects [7, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38].
Characteristics of Aneurysms
There were 414 patients with 448 IAs, including 374 (83.5 %) and 74 (16.5 %) in the anterior and posterior circulations, respectively. There were 351 (78.3 %) saccular or blister-like, 69 (15.4 %) fusiform, and 28 (6.3 %) dissecting IAs. All except two studies included a mixture of saccular and dissecting/fusiform IAs [18, 20]. Based on 387 IAs with available information, the mean IA size was calculated to be 12.0 mm. The lowest mean IA size per study was 3.8 mm, and the largest was 18.2 mm. There were 171 (38.9 %) small (< 10 mm), 177 (40.2 %) large (10–25 mm), and 53 (12.1 %) giant (> 25 mm) IAs. The remaining 46 (10.3 %) cases included 38 dissecting IAs and eight saccular IAs which the authors did not further categorize by size . Based on seven studies that described clinical presentations (n = 301), the majority of the IAs was asymptomatic (n = 152 or 50.1 %), followed by the presence of mass effect and cranial nerve palsies (n = 51 or 16.9 %). Sixteen (3.6 %) IAs were treated soon after acute subarachnoid hemorrhages (SAHs). Another 37 (8.3 %) IAs had previously ruptured but were not treated in the context of acute SAH. Prior to the placement of the PED, 125 (27.9 %) lesions had received other treatments such as surgical clipping, coiling, and/or stenting (Table 1).
Characteristics of the aneurysms treated with the pipeline embolization device in ten eligible studies
Number of patients (IA)
Mean sized (mm)
Clinical presentations by IAs
Number of PED used (mean number per IA)
McAuliffe et al. 
46 saccular; 11 fusiform
46 Ant; 11 Post
18 small; 32 large; 7 giant
41 asymptomatic; 16 mass effect
15 EVT; 1 clipping
McAuliffe and Wenderoth 
3 saccular; 5 blister; 3 fusiform
5 Ant; 6 Post
4 small; 6 large; 1 giant
6 within 2 weeks; 5 within 2–4 weeks post-SAH
1 coiling; 2 stent + coil
Nelson et al.  “PITA”
29 Ant; 2 Post
20 small; 9 large; 2 giant
8 coiling; 2 stenting; 2 coil + stent
Lubicz et al. 
16 saccular; 11 fusiform
24 Ant; 3 Post
24 small; 3 large
1 acute SAH; 1 hemiparesis;18 asymptomatic
9 IAs (details not known)
De Barros Faria et al. 
2 Ant; 21 Post
7 small; 7 large; 9 giant
5 asymptomatic; 5 mass effects; 1 ischemia; 12 past SAHs
Fischer et al. 
63 saccular; 33 fusiform; 5 dissecting
79 Ant; 22 Post
3.8 (saccular IA only)
Saccular—60 small; 3 large; Undetermined in 38 dissecting
61 asymptomatic; 18 past SAHs; 9 cranial nerve palsies; 13 symptomatic dissection
30 stenting; 9 coiling; 9 clipping
66 % IAs had > 1 PED
Food and Drug Administrationa 
1 small; 85 large; 22 giant
8 coiling; 1 clipping; 1 other
Szikora et al.b 
16 saccular; 3 fusiform
18 Ant; 1 Post
5 small; 10 large; 4 giant
10 headaches; 6 mass effect; 1 failed past EVT; 2 asymptomatic
1 EVT (details not known)
Lylyk et al.c 
55 saccular; 8 fusiform
55 Ant; 8 Post
33 small; 22 large; 8 giant
25 asymptomatic; 6 headaches; 7 previous SAHs; 4 mass effects; 5 visual deficits; 6 cranial nerve palsies
14 coiling; 6 stent + coil; 1 stenting; 2 clipping
Food and Drug administration 
351 saccular/blister-like; 69 fusiform; 28 dissecting
374 Ant; 74 Post
171 small; 177 large; 53 giant; 46 undetermined
Antiplatelet and Anticoagulating Therapies
The regimens of antiplatelet therapy and heparinization varied between and within studies. One study did not describe these in details . Before surgery, all patients received aspirin and clopidogrel. These may be started at least 1 day [13, 19], 2 days [15, 17], 3 days [9, 18], 5 days [13, 15], or 7 days  prior to surgery. The dosage of aspirin ranged from 100 to 150 mg, and that of clopidogrel from 75 to 600 mg. Point-of-care platelet inhibition tests were used in some centers [15, 19]. Heparinization was used to achieve an activated clotting time of more than 200 s. This was continued for at least 24 h post-operatively, except in one study in which heparinization was stopped by the end of the procedure . After surgery, dual antiplatelet agents were continued for at least 3 months although aspirin was commonly continued for another 3 months [9, 12, 18] or even life-long . Six months of dual agents may be used when the PED was covering a side branch . The duration of treatment may also depend on whether the IA affected the anterior (6 months) or the posterior (12 months) circulation [14, 15].
More than 811 devices were used to treat 448 IAs; the exact number was not available in one study . Based on the remaining nine studies, the mean number of PED used was 2.0 per IA. The mean number of PED used per study ranged from 1.0 to 3.2 for each IA. Only one study did not employ multiple devices at all . Fifty-four lesions were treated with adjuvant coiling. Technical problems, including failed and suboptimal deployment, occurred during 23 procedures (5.1 %).
Procedure-related complications and outcomes of aneurysms treated with the pipeline embolization device
Number of IAs
Symptomatic procedure-related complications
Number of complete IA occlusion/number assessed
Recanalization after initial occlusion
McAuliffe et al. 
1 poor deployment
4 TIAs; 3 transient worsening of mass effect; 1 retroperitoneal hematoma
48/56 at 6 mos
2 stenosis 2 migration
McAuliffe and Wenderoth 
1 poor deployment
2 IA ruptures; 1 cerebellar ICH
8/9 at 6 mos
1 stenosis 1 migration
Nelson et al. 
1 failed deployment
1 ICA rupture; 1 ischemic infarction
28/30 at 6 mos
Lubicz et al. 
9 “minor technical issues”
1 ICH; 1 SAH (not IA related); 1 retroperitoneal hematoma
21/25 at 4–6 mos
All survivors had mRS = 0
De Barros Faria et al. 
5 “technical issues”
1 ischemic stroke; 1 retroperitoneal hematoma
16/23 at 6 mos
74 % GOS 4 or 5
Fischer et al. 
1 failed deployment
1 IA rupture; 2 ischemic infarctions; 3 ICHs
47/90 at 3; 36/49 at 10 mos
Food and Drug Administrationa 
1 device failure
2 ICHs; 3 ischemia infarctions; 1 unknown fatal event
78/106 at 6 mos
2 at 12 mos
6 of 100 assessed worsened; others unchanged or improved
Szikora et al. 
2 failed deployment
2 ischemic infarctions; 1 embolic occlusion of retinal artery; 1 SAH
17/18 at 6 mos
7 unchanged; 6 of 6 mass effects improved, 5 of 10 headaches improved
Lylyk et al. 
2 failed deployment
3 worsening of pre-existing cranial nerve palsies due to mass effect; 5 femoral hematomas; 1 contrast allergy
62/63 at 12 mos
54 of 56 assessed were unchanged; 2 improved
Food and Drug Administration 
1 fatal ICH, 1 femoral pseudoaneurysm, 2 retroperitoneal hematomas
5/6 at 6 mos
3 IA ruptures; 14 ischemic events; 11 non-IA-related intracranial hemorrhagic events; 6 worsening of mass effects; 1 unknown nature; 11 puncture-site hematoma
Procedure-Related Complications and Mortalities (Table 2)
We have included complications that were deemed to be procedure-related by the authors of the eligible studies. In analyzing the PUFS, which had an elaborate protocol guiding the reporting of adverse events, we only included those complications defined under the study’s “primary safety endpoint” (i.e., the occurrence of major ipsilateral stroke or neurologic death by 180 days after treatment) . From all ten studies, there were three cases of IA ruptures, 14 ischemic events, 11 non-IA-related intracranial hemorrhages, six cases of worsening of mass effect, 11 femoral or retroperitoneal hematomas, and one fatal event of unknown nature. This yielded an overall symptomatic complication rate of 10.3 % (n = 46) for 447 IAs. If only intracranial vascular (i.e., ischemic or hemorrhagic) events were included, the complication rate was 6.3 % (n = 28). Procedure-related mortalities occurred in nine (2.2 %) of the 413 patients. The causes of death were due to rebleedings from recently ruptured IAs (two cases) , bleeding from previously nonruptured IAs (two cases) [17, 19], ipsilateral intracranial hemorrhage not related to IA (three cases) [12, 20], delayed arterial thrombosis (one case) , and one neurologic event of unknown nature . When only previously nonruptured IAs were analyzed (n = 394), the major intracranial vascular complication and mortality rates were 6.1 and 0.8 %, respectively. For IAs treated in the context of recent SAH (n = 16), the major intracranial vascular complication and mortality rates were 18.8 and 12.5 %, respectively.
Angiographic and Clinical Outcomes (Table 2)
Follow-up arrangements varied between and within studies. Eight studies reported angiographic follow-up at 6-month or beyond for a total of 354 IAs. Complete obliteration was achieved in 293 (82.8 %) lesions. Another study had follow-up durations ranging from 2 to 6 months, and reported an obliteration rate of 84 % . We also looked at 50 IAs that had previously been treated with conventional stenting. One study treated 30 IAs of these but it was not clear how many had follow-up angiography. The observed obliteration rate was stated as 65 % by the author . Based on the assumption that all had follow-up angiographies, the obliteration rate for this subgroup was 68 % (or 34 in 50 IAs; Table 3). In-stent stenosis or thrombosis on angiograms occurred in 21 cases. Recanalization was uncommon (two cases) although few studies conducted longitudinal follow-up angiographic studies after confirmed obliteration .
Outcome of aneurysms with previous stenting
Number of IAs with previous stenting
Number of complete obliterations
Number of PED-related complications
McAuliffe et al. 
McAuliffe and Wenderoth 
Fischer et al. 
2 ischemic infarctions; 2 ICHs
Nelson et al. 
1 ischemic infarction
De Barros Faria et al. 
Lylyk et al. 
Five studies reported clinical outcomes using various parameters. Neurologic deterioration was uncommon among survivors . The majority of patients were asymptomatic and well before surgery and had remained so afterward [9, 12, 13, 18]. In one study, symptomatic improvement was reported in 50 % of those with headaches, and in all patients presented with mass effects from their IAs .
Fifty IAs were treated with stenting prior to PED placement. Complete obliterations occurred in 34 (68 %). Intracranial vascular complications occurred in five (10 %) of these 50 lesions, compared with 22 (5.6 %) in 390 lesions without previous stenting (Table 3).
Currently, there are two main flow diverters commercially available for use, namely the PED and the SILK flow diverters (SFD, Balt Extrusion, Montmorency, France) . Based on two recent reports, the SILK could achieve a similar IA obliteration rate as the PED (around 80 %); the former, however, appeared to be associated with a higher early complication rate of around 17 % [40, 41]. Reported studies on SILK are too few to allow for a side-by-side comparison, and we focused only on the PED in the present review. The PED is designed to address several critical problems in the EVT of IAs . With coil embolization, reconstitution of the IAs may occur due to coil compaction. Catheterization of the IAs may potentially cause rupture, and wide-necked IAs may not hold the coils in place despite the use of stent assistance or balloon assistance . The coils also form a permanent mass in the IAs that may potentially worsen any preexisting mass effect. With the PED, there is no manipulation within the IAs, and adjuvant coiling is not necessary though feasible. The PED also has other theoretical advantages. The device forms a scaffold upon which endothelial regrowth can occur, leading to the full coverage of the implant and the aneurysm neck. When compared with self-expanding or balloon-expandable stents, the PED has higher metal surface area coverage, which greatly facilitates the occlusion of the aneurysm neck and neointimal regrowth. However, the degree to which this neointimal remodeling occurs is unknown, and very late in-stent thrombosis has been known to occur . Ideally, the thrombotic clot within the IAs is reabsorbed by normal healing processes, leading to shrinkage of the IAs, a reduction of mass effect, and a potentially lower risk of recanalization. But even under highly controlled experimental conditions, complete obliteration is by no means the rule , and as discussed in the following section, the PED may actually worsen preexisting mass effect. Because of the PED’s porosity, outflow in perforators and side branches can be maintained although long-term follow-up data are lacking . Puffer et al.  studied the treatment of 20 paraclinoid IAs, and reported that in fact up to a quarter of ophthalmic arteries would undergo proximal thrombosis when covered with the PED. Moreover, whether the PED would be effective for bifurcation IAs or well tolerated in the presence of preexisting perforator stenosis is still unknown.
Based on the reviewed studies, the PED was used mostly for the treatment of IAs that had failed or were considered unsuitable for conventional endosaccular embolization or endoluminal stenting. The majority of the lesions were large, asymptomatic, and saccular IAs situated in the anterior circulation. The need for endoluminal coverage for these relatively large-sized lesions may account for the large number of multiple devices used. Experiences with the PED in the treatment of dissecting IAs were comparatively limited. The available data did not allow a subgroup analysis, which would have been of interest given the different natural histories between saccular and dissecting IAs [14, 15, 18, 19]. De Barros Faria et al.  treated 23 dissecting aneurysms with the PED and reported an overall occlusion rate of 87.5 %. Good clinical outcome was achieved in 74 % of patients . Individual case reports have also described the successful use of the PED for nonruptured  and ruptured  dissecting aneurysms. Further studies are needed to investigate the safety and efficacy of this particular application.
Fargen et al.  have recently reviewed complications associated with the PED in the treatment of 374 nonruptured IAs. It reported a major complication rate and a mortality rate of 5.3 and 1.3 %, respectively. Our review included three additional studies and yielded similar findings. We also included IAs that were treated in the context of acute SAH which is still a matter of controversy [14, 34, 35]. After PED placement, healing of the IAs is delayed while the procedure itself requires antiplatelet and anticoagulating therapies, which can be problematic in the event of a rerupture. We found that two of the 16 recently ruptured IAs rebled soon after treatment and resulted in mortalities. Both reruptured IAs were situated in the anterior circulation while all posterior circulation lesions were treated successfully. The complication and mortality rates for this subgroup were considerably higher than those of nonruptured IAs, but this may partly be due to the small number of cases involved. McAuliffe and Wenderoth  suggested the use of adjuvant coiling to secure the aneurysm fundus first, followed by PED placement and the completion of coiling. However, balloon-assisted coiling may not be technically feasible for IAs that incorporate much of the wall of the native vessels for which the PED was indicated in the first place. In any case, there is at present not enough evidence to support the routine use of the PED in the context of a recent rupture. The concern for PED-induced rupture is further heightened by reports of delayed hemorrhages from otherwise silent IAs following PED placement [23, 31, 37]. In our review, we found that two of the four post-PED ruptures involved previously nonruptured IAs. The underlying mechanism was unclear. Mural destabilization and hemodynamic alteration from a PED have been proposed as possible causes [31, 43]. Similarly, delayed ruptures have been reported with the SILK diverter . To our knowledge, no predisposing factors have been identified. At present, the small number of ruptured cases precluded meaningful risk analysis.
There were also 11 non-IA-related hemorrhagic complications. The majority (n = 7) were intracerebral hemorrhages (ICH) adjacent to or within the dependent territories of the treated arterial segments [12, 13, 16, 19, 20]. This yielded an incidence of 1.6 % for non-IA-related ICHs within the anterior circulation. The underlying mechanisms were likely to be heterogeneous. Post-PED hemodynamic alterations and hemorrhagic transformation of ischemic infarctions were possible explanations. In addition, IAs with previous stenting had a high rate of vascular complications, possibly due to compromised maneuverability during PED deployment. As with intraluminal stents, thromboembolism is a serious concern after PED placement. Although the use of antiplatelet therapy was universal, the regimens varied greatly in details. Hyporesponsiveness to antiplatelet therapy is a well-recognized phenomenon, and may be associated with coronary stent thrombosis  as well as thromboembolic complications during IA embolization . Only a few centers used point-of-care platelet function tests although whether high on-treatment platelet activity contributed to the occurrence of ischemic complications is difficult to ascertain . Interestingly, one study that used point-of-care tests also reported a high incidence of transient ischemic attack but this may be due to an increased alertness and detection bias .
The worsening of preexisting mass effects is an interesting finding in that, unless adjuvant coiling is used, the PED does not result in a coil mass and the IAs are supposed to shrink following treatment. Lylyk et al.  treated three giant IAs that were causing cranial nerve palsies, and all had postoperative deteriorations despite steroids cover. All eventually improved. McAuliffe et al.  treated 16 IAs that were causing mass effects before surgery. The sizes of the lesions were not reported. Eight received steroids cover and three experienced worsening of symptoms. How many of these cases involved coiling was not clear. Inflammatory responses secondary to endosaccular thrombosis were likely to be responsible. Conversely, Szikora et al.  treated six IAs with mass effects and all improved after surgery. These findings highlight the importance of collecting solid clinical evidence to support the theoretical advantages of the PED.
Aneurysm Obliteration and Recanalization
The mechanism of action of the PED does not depend on the size, the configuration, or the dense packing of the aneurysm sac. It is therefore particularly effective for the treatment of some of the challenging IAs. We found an overall obliteration rate of more than 80 % at 6-month, which compares favorably with that of stent-assisted  or balloon-assisted embolization . Recanalization was also uncommon although there were very few follow-up studies after confirmed obliterations. The IAs in the reviewed series were too heterogeneous and the available information not comprehensive enough to allow the identification of predisposing features of incomplete occlusion. We did, however, found a lower obliteration rate in IAs that had previously undergone stenting procedures. Several authorities suggested that the presence of a stent may reduce the chance of PED-induced obliteration by complicating deployment, impairing the apposition of the stent to the arterial wall and disrupting neointimal remodeling [9, 16]. This should be taken into considerations during treatment planning for IAs that are potentially suitable for the PED.
Limitations of Study
It must be emphasized that the majority of the reviewed studies were self-adjudicated single-center studies with varied, relatively short or incomplete follow-ups. This may potentially result in underestimations of the overall complication rate as well as the number of eventual recoveries from initially unfavorable outcomes. For instance, in the PUFS, some cases of hemorrhagic complications did not reach primary endpoints and were therefore not included in our analysis. Both the PUFS and COCOA reports consisted of only on-line documents based on a company-driven registry, and their results should be considered with care . Furthermore, two studies had patients that overlapped with those in the PITA which may affect the accuracy of our analysis.
The PED is a feasible, effective, and safe method for the endoluminal treatment of nonruptured IAs. Its use in the treatment of recently ruptured IAs is associated with a relatively high rate of rebleeding and should be cautioned. Previous stenting may also result in poorer outcome. Recanalization after complete obliteration, in-stent stenosis and thrombosis are uncommon. The main limitations of the PED include the need for prolonged antiplatelet therapy, and the potential risks of delayed rupture, non-IA-related ICH, worsening of preexisting mass effect, and reduced efficacy with previous stenting. Flow-diverting devices represent an important advancement in the treatment of IAs although many of the theoretical advantages of the PED such as aneurysm shrinkage and neointimal remodeling are yet to be proven experimentally or clinically. Randomized studies comparing the PED with conventional EVT are methodologically difficult since each modality has its unique indications in terms of IA characteristics. Future studies may aim at identifying factors that predispose to incomplete occlusion, PED-induced rupture, and thromboembolic complications.
Conflict of Interest
The authors have no funding or any potential conflict of interest to declare.
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