, Volume 44, Issue 5, pp 440–444 | Cite as

Palliative care in heart failure

A meta-analysis of randomized controlled trials
  • K. Zhou
  • Y. MaoEmail author
Review articles



Palliative care can play an important role in the management of heart failure. We conducted a systematic review and meta-analysis to compare the efficacy and safety of palliative care in patients with heart failure.


PubMed, Embase, Web of Science, EBSCO, and the Cochrane Library databases were systematically searched. Randomized controlled trials (RCTs) on the impact of palliative care on heart failure were included. Two investigators independently searched the articles, extracted data, and assessed the quality of included studies. The primary outcome was mortality.


Seven RCTs were included in the meta-analysis. Compared with usual care for heart failure, palliative care was associated with a significantly increased quality of life (standardized mean difference = 1.46; 95% confidence interval [CI] = 0.12 to 2.79; p = 0.03) and reduced depression scores (standardized mean difference = −0.62; 95% CI = −0.99 to −0.25; p = 0.03), but demonstrated no impact on mortality (risk ratio [RR] = 1.28; 95% CI = 0.86 to 1.92; p = 0.22) and rehospitalization (RR = 0.84; 95% CI = 0.66 to 1.07; p = 0.16).


Palliative care can improve the quality of life and reduce the occurrence of depression in patients with heart failure.


Palliative therapy Myocardial failure Mortality Randomized controlled trial Meta-analysis 

Palliativversorgung bei Herzinsuffizienz

Metaanalyse randomisierter kontrollierter Studien



Die Palliativversorgung kann eine wichtige Rolle in der Behandlung der Herzinsuffizienz spielen. Die Autoren führten eine systematische Suche und eine Metaanalyse durch, um die Wirksamkeit und Sicherheit der Palliativversorgung bei Patienten mit Herzinsuffizienz zu vergleichen.


Die Datenbanken PubMed, Embase, Web of Science, EBSCO und die Cochrane Library wurden systematisch durchsucht. In die Auswertung aufgenommen wurden randomisierte kontrollierte Studien (RCT) zum Einfluss der Palliativversorgung auf die Herzinsuffizienz. Unabhängig voneinander suchten 2 Untersucher die Artikel heraus, extrahierten Daten und beurteilten die Qualität der in die Auswertung eingeschlossenen Studien. Primärer Endpunkt war die Mortalität.


In die Metaanalyse wurden 7 RCT eingeschlossen. Im Vergleich zur gewöhnlichen Behandlung bei Herzinsuffizienz ging die Palliativversorgung mit einer signifikant erhöhten Lebensqualität einher (standardisierte Mittelwertsdifferenz = 1,46; 95%-Konfidenzintervall (KI) = 0,12–2,79; p = 0,03) sowie mit geringeren Depressionsscores (standardisierte Mittelwertsdifferenz = −0,62; 95%-KI = −0,99–−0,25; p = 0,03), zeigte jedoch keine Auswirkung auf die Mortalität (Risk Ratio [RR] = 1,28; 95%-KI = 0,86–1,92; p = 0,22) und eine erneute stationäre Aufnahme (RR = 0,84; 95%-KI = 0,66–1,07; p = 0,16).


Palliativversorgung kann die Lebensqualität verbessern und das Auftreten von Depressionen bei Patienten mit Herzinsuffizienz verringern.


Palliativtherapie Myokardinsuffizienz Mortalität Randomisierte kontrollierte Studie Metaanalyse 


Compliance with ethical guidelines

Conflict of interest

K. Zhou and Y. Mao declare that they have no competing interests.

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Department Rehabilitation MedicineNingbo No. 2 HospitalNingboChina
  2. 2.Emergency DepartmentNinghai First HospitalNinghaiChina

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