Advertisement

Herz

, Volume 39, Issue 7, pp 867–870 | Cite as

Benign metastasizing leiomyoma

Case report and review of the literature
  • A. Cai
  • L. Li
  • H. Tan
  • Y. Mo
  • Y. ZhouEmail author
e-Herz: Case study

Abstract

Benign metastasizing leiomyoma (BML) is a rare clinical condition predominantly occurring in reproductive women with a history of uterine leiomyoma resection or hysterectomy. Oftentimes, it is easy to be misdiagnosed as a malignant tumor when nodules are found in multiple tissues. In order to raise clinicians’ awareness of BML, we present a short review of the literature in combination with an unusual case.

Keywords

Benign metastasizing leiomyoma Uterine leiomyoma Hysterectomy Review Case report 

Benignes metastasierendes Leiomyom

Kasuistik und Literaturübersicht

Zusammenfassung

Ein benignes metastasierendes Leiomyom (BML) ist eine seltene Erkrankung, die bei Frauen im fortpflanzungsfähigen Alter mit Resektion eines Leiomyoms der Gebärmutter oder Hysterektomie in der Anamnese vorkommt. In vielen Fällen ist es leicht als maligner Tumor fehlzudiagnostizieren, wenn sich Knötchen in mehreren Geweben finden. Um das Bewusstsein der klinisch tätigen Ärzte für ein BML zu erhöhen, werden Erkenntnisse zum BML in der vorliegenden Literatur zusammen mit einem ungewöhnlichen Fall dargestellt.

Schlüsselwörter

Benignes metastasierendes Leiomyom Uterines Leiomyom Hysterektomie Übersichtsarbeit Kasuistik 

Notes

Acknowledgments

We thank Dr. Liu Yanhui, Dr. Mei Ping, and Dr. Liu Hui very much for their kind help.

Conflict of interest

On behalf of all authors, the corresponding author states that there are no conflicts of interest.

References

  1. 1.
    Kayser K, Zink S, Schneider T et al (2000) Benign metastasizing leiomyoma of the uterus: documentation of clinical, immunohistochemical and lectin-histochemical data of ten cases. Virchows Arch 437(3):284–292PubMedCrossRefGoogle Scholar
  2. 2.
    Arai T, Yasuda Y, Takaya T, Shibayama M (2000) Natural decrease of benign metastasizing leiomyoma. Chest 117(3):921–922PubMedCrossRefGoogle Scholar
  3. 3.
    Wongsripuemtet J, Ruangchira-urai R, Stern EJ et al (2012) Benign metastasizing leiomyoma. J Thorac Imaging 27(2):W41–W43PubMedCrossRefGoogle Scholar
  4. 4.
    Fasih N, Prasad SAK, Macdonald DB et al (2008) Leiomyomas beyond the uterus: unusual locations, rare manifestations. Radiographics 28(7):1931–1948PubMedCrossRefGoogle Scholar
  5. 5.
    Rivera JA, Christopoulos S, Small D, Trifiro M (2004) Hormonal manipulation of benign metastasizing leiomyomas: report of two cases and review of the literature. J Clin Endocrinol Metab 89(7):3183–3188PubMedCrossRefGoogle Scholar
  6. 6.
    Thukkani N, Ravichandran PS, Das A, Slater MS (2005) Leiomyomatosis metastatic to the tricuspid valve complicated by pelvic hemorrhage. Ann Thorac Surg 79(2):707–709PubMedCrossRefGoogle Scholar
  7. 7.
    Tietze L, Gunther K, Horbe A et al (2000) Benign metastasizing leiomyoma: a cytogenetically balanced but clonal disease. Hum Pathol 31(1):126–128PubMedCrossRefGoogle Scholar
  8. 8.
    Bowen JM, Cates JM, Kash S et al (2012) Genomic imbalances in benign metastasizing leiomyoma: characterization by conventional karyotypic, fluorescence in situ hybridization, and whole genome SNP array analysis. Cancer Genet 205(5):249–254PubMedCentralPubMedCrossRefGoogle Scholar
  9. 9.
    Jautzke G, Muller-Ruchholtz E, Thalmann U (1996) Immunohistological detection of estrogen and progesterone receptors in multiple and well differentiated leiomyomatous lung tumors in women with uterine leiomyomas (so-called benign metastasizing leiomyomas). A report on 5 cases. Pathol Res Pract 192(3):215–223PubMedCrossRefGoogle Scholar
  10. 10.
    Abu-Rustum NR, Curtin JP, Burt M, Jones WB (1997) Regression of uterine low-grade smooth-muscle tumors metastatic to the lung after oophorectomy. Obstet Gynecol 89(5 Pt 2):850–852PubMedCrossRefGoogle Scholar
  11. 11.
    Hoetzenecker K, Ankersmit HJ, Aigner C et al (2009) Consequences of a wait-and-see strategy for benign metastasizing leiomyomatosis of the lung. Ann Thorac Surg 87(2):613–614PubMedCrossRefGoogle Scholar
  12. 12.
    Fasih N, Prasad SAK, Macdonald DB et al (2008) Leiomyomas beyond the uterus: unusual locations, rare manifestations. Radiographics 28(7):1931–1948PubMedCrossRefGoogle Scholar
  13. 13.
    Abu-Rustum NR, Curtin JP, Burt M, Jones WB (1997) Regression of uterine low-grade smooth-muscle tumors metastatic to the lung after oophorectomy. Obstet Gynecol 89(5 Pt 2):850–852PubMedCrossRefGoogle Scholar
  14. 14.
    Rege AS, Snyder JA, Scott WJ (2012) Benign metastasizing leiomyoma: a rare cause of multiple pulmonary nodules. Ann Thorac Surg 93(6):e149–e151PubMedCrossRefGoogle Scholar
  15. 15.
    Abramson S, Gilkeson RC, Goldstein JD et al (2001) Benign metastasizing leiomyoma: clinical, imaging, and pathologic correlation. AJR Am J Roentgenol 176(6):1409–1413PubMedCrossRefGoogle Scholar
  16. 16.
    Steiner PE (1939) Metastasizing fibroleiomyoma of the uterus: Report of a case and review of the literature. Am J Pathol 15(1):89–110.7PubMedCentralPubMedGoogle Scholar

Copyright information

© Urban & Vogel 2013

Authors and Affiliations

  1. 1.Department of Cardiology, Guangdong Cardiovascular InstituteGuangdong General Hospital, Guangdong Academy of Medical SciencesGuangzhouChina

Personalised recommendations