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Herz

, Volume 38, Issue 1, pp 93–96 | Cite as

Familial Takayasu arteritis in a mother and daughter: a report of two cases

  • A. DenizEmail author
  • F. Yildiz
  • H. Aktas
  • G.I. Berk
  • E. Erken
  • M. Demirtas
e-Herz: Case study

Abstract

Takayasu arteritis (TA) is a chronic granulomatous panarteritis, predominantly affecting the aorta and its main branches. Infections, genetic factors as suggested by familial clustering, and autoimmunity may play a role in its pathogenesis. In this report, we describe familial TA in a mother and daughter with diverse clinical manifestations. In addition to being a familial form of vasculitis, both of our cases demonstrated amyloidosis, chronic renal disease thought to be due to ischemic nephropathy, and hypertensive nephrosclerosis.

Keywords

Amyloidosis Chronic renal disease Familial Takayasu arteritis Hypertension 

Familiäre Takayasu-Arteriitis bei Mutter und Tocher: Bericht über 2 Fälle

Zusammenfassung

Bei der Takayasu-Arteriitis (TA) handelt es sich um eine chronische granulomatöse Panarteriitis, die in erster Linie die Aorta und ihre Hauptäste betrifft. Infektionen, genetische Faktoren, wie Hinweise durch familiäres Clustering ergaben, und Autoimmunität können eine Rolle in der Pathogenese spielen. Hier wird eine familiäre TA bei Mutter und Tochter mit verschiedenen klinischen Manifestationen beschrieben. Neben einer familiären Form der Vaskulitis wiesen beide Fälle eine Amyloidose, eine chronische Niereninsuffizienz – vermutlich infolge ischämischer Nephropathie – und eine hypertensive Nephrosklerose auf.

Schlüsselwörter

Amyloidose Chronische Niereninsuffizienz Familiäre Takayasu-Arteriitis Hypertonie 

Notes

Conflict of interest

On behalf of all authors, the corresponding author states that there are no conflicts of interest.

Supplementary material

Video of renal angiography demonstrating severe in-stent restenosis in left renal artery (QickTime.mov 0,5 MB)

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Copyright information

© Urban & Vogel, Muenchen 2012

Authors and Affiliations

  • A. Deniz
    • 1
    Email author
  • F. Yildiz
    • 2
  • H. Aktas
    • 1
  • G.I. Berk
    • 1
  • E. Erken
    • 2
  • M. Demirtas
    • 1
  1. 1.Department of CardiologyFaculty of Medicine, Çukurova UniversityAdanaTurkey
  2. 2.Department of RheumatologyFaculty of Medicine, Çukurova UniversityAdanaTurkey

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