Synthesis of dehydro-α-lapachones, α- and β-lapachones, and screening against cancer cell lines
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14 new naphthoquinones were prepared and tested against human cancer cell lines PC-3 (prostate), HCT-116 (colon carcinoma), SNB-19 (glioblastoma), HL-60 (leukemia) and MCF-7 (breast), and a nontumor cell line L929 (murine fibroblasts) to determine cytotoxicity with the MTT assay. 8-OH-β-lapachones (14a, 14c, 14d) presented best results, showing low IC50 values and high selectivity for HCT-116 and HL-60 tumor cells.
KeywordsNaphthoquinone Cancer Dehydro-α-lapachone Lapachone Xyloidone
Fellowships granted by CNPq, CAPES and FAPERJ are gratefully acknowledged. This work was partially supported by FAPERJ grant numbers E-26/201.448/2014, CNPq 440755/2018-2, and CNPq 303713/2014-3. The also author thanks FIOCRUZ for the HRESIMS.
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Conflict of interest
The authors declare that they have no conflict of interest.
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