Synthesis and biological evaluation of novel triazolyl 4-anilinoquinazolines as anticancer agents

  • Hani Mutlak A. HassanEmail author
  • Iuliana Denetiu
  • Salman A. Khan
  • Mohd Rehan
  • Kaltoom Sakkaf
  • Kalamegam Gauthaman
Original Research


The synthesis of novel triazolyl 4-anilinoquinazolines in five sequential synthetic steps via copper-catalyzed click chemistry and their anticancer biological evaluation is described.


Quinazolines Triazoles Click chemistry Anticancer 



This work was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, under grant number G-203-141-1436. We, therefore, thank DSR for financial support.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Hani Mutlak A. Hassan
    • 1
    Email author
  • Iuliana Denetiu
    • 1
  • Salman A. Khan
    • 2
  • Mohd Rehan
    • 1
  • Kaltoom Sakkaf
    • 3
  • Kalamegam Gauthaman
    • 4
  1. 1.King Fahd Medical Research CenterKing Abdulaziz UniversityJeddahSaudi Arabia
  2. 2.Department of Chemistry, Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia
  3. 3.Department of Medical Laboratory TechnologyFaculty of Applied Medical SciencesJeddahSaudi Arabia
  4. 4.Center of Excellence in Genomic Medicine ResearchKing Abdulaziz UniversityJeddahSaudi Arabia

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