Synthesis and anticancer activity evaluation of novel oxacalixarenepyrimidine derivatives
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A series of novel oxacalixarenepyrimidine derivatives were synthesized, and their antitumor activities against HeLa, MCF7, HepG2, and A549 human cancer cell lines were evaluated using an MTT assay. Some of the synthesized compounds exhibited considerable anti-proliferative activity against the human cancer cell lines. Compound 5l, which contains an ethanolamine moiety, exhibited the strongest inhibitory activity against HepG2 with an IC50 value of 12.37 μM. Moreover, a cell apoptosis assay indicated that the anti-proliferative activity of 5l might be attributed to its induction of apoptosis. Our report highlights the potential anticancer efficacy of novel oxacalixarenepyrimidines.
KeywordsOxacalixarenepyrimidine Ethanolamine Anticancer Apoptosis
This study was funded by the grants from Natural Science Foundation of Jiangsu Province (BK20171184; BK20170258), Jiangsu Planned Projects for Postdoctoral Research Funds (1701132C), Technology Plan Projects of Xuzhou (KC17091), and Postgraduate Research & Practice Innovation Program of Jiangsu Province (KYCX18-2203).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
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