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Synthesis and anticancer activity evaluation of novel oxacalix[2]arene[2]pyrimidine derivatives

  • Tonghui Huang
  • Xin Wu
  • Tianya Liu
  • Lin An
  • Xiaoxing YinEmail author
Original Research
  • 54 Downloads

Abstract

A series of novel oxacalix[2]arene[2]pyrimidine derivatives were synthesized, and their antitumor activities against HeLa, MCF7, HepG2, and A549 human cancer cell lines were evaluated using an MTT assay. Some of the synthesized compounds exhibited considerable anti-proliferative activity against the human cancer cell lines. Compound 5l, which contains an ethanolamine moiety, exhibited the strongest inhibitory activity against HepG2 with an IC50 value of 12.37 μM. Moreover, a cell apoptosis assay indicated that the anti-proliferative activity of 5l might be attributed to its induction of apoptosis. Our report highlights the potential anticancer efficacy of novel oxacalix[2]arene[2]pyrimidines.

Keywords

Oxacalix[2]arene[2]pyrimidine Ethanolamine Anticancer Apoptosis 

Notes

Acknowledgements

This study was funded by the grants from Natural Science Foundation of Jiangsu Province (BK20171184; BK20170258), Jiangsu Planned Projects for Postdoctoral Research Funds (1701132C), Technology Plan Projects of Xuzhou (KC17091), and Postgraduate Research & Practice Innovation Program of Jiangsu Province (KYCX18-2203).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

44_2019_2321_MOESM1_ESM.pdf (1 mb)
Supplementary Information

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Tonghui Huang
    • 1
    • 2
  • Xin Wu
    • 1
  • Tianya Liu
    • 3
  • Lin An
    • 1
  • Xiaoxing Yin
    • 1
    Email author
  1. 1.Jiangsu Key Laboratory of New Drug Research and Clinical PharmacyXuzhou Medical UniversityXuzhouPeople’s Republic of China
  2. 2.Xuzhou Medical University Science ParkXuzhouPeople’s Republic of China
  3. 3.Department of PharmacyThe Affiliated Hospital of Xuzhou Medical UniversityXuzhouPeople’s Republic of China

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