Synthesis and antitumor activity evaluation of different 2,5-dialkyloxazolopyrano[3,2-c]quinolinone derivatives
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A new interesting family of 2,5-dialkyloxazolopyrano[3,2-c]quinolinone derivatives 4a-l were synthesized in good yields using a convenient and successful method. Structures of all compounds were achieved by elemental analyses, IR, 1H NMR, 13C NMR, and mass techniques. The tetracyclic homologues 4a-l were evaluated for antitumor activity and cytotoxicity against a board of three human cancer cell lines (HepG-2, MCF-7, and HCT-116). The cells were treated with these compounds at differentiable dosages, and cell viability was determined. Significant anticancer activities were observed in vitro for some members of the series related to 5-fluorouracil and compounds 4c and 4f showed potent cytotoxic effect, that creates these compounds were disclosed as the most applicable anticancer agents against different cancer cell lines.
KeywordsDialkyloxazole Pyranoquinolinone Antitumor activity Cell line Cell viability Cytotoxicity
This work was accomplished under national funding from General Administration of Environment Projects, Ain Shams University.
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Conflict of interest
The authors declare that they have no conflict of interest.
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