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Medicinal Chemistry Research

, Volume 28, Issue 1, pp 28–38 | Cite as

Synthesis and antitumor activity evaluation of different 2,5-dialkyloxazolopyrano[3,2-c]quinolinone derivatives

  • Hany M. Hassanin
  • Wafaa R. Abd Elmoneam
  • Mai A. MostafaEmail author
Original Research
  • 64 Downloads

Abstract

A new interesting family of 2,5-dialkyloxazolopyrano[3,2-c]quinolinone derivatives 4a-l were synthesized in good yields using a convenient and successful method. Structures of all compounds were achieved by elemental analyses, IR, 1H NMR, 13C NMR, and mass techniques. The tetracyclic homologues 4a-l were evaluated for antitumor activity and cytotoxicity against a board of three human cancer cell lines (HepG-2, MCF-7, and HCT-116). The cells were treated with these compounds at differentiable dosages, and cell viability was determined. Significant anticancer activities were observed in vitro for some members of the series related to 5-fluorouracil and compounds 4c and 4f showed potent cytotoxic effect, that creates these compounds were disclosed as the most applicable anticancer agents against different cancer cell lines.

Keywords

Dialkyloxazole Pyranoquinolinone Antitumor activity Cell line Cell viability Cytotoxicity 

Notes

Acknowledgements

This work was accomplished under national funding from General Administration of Environment Projects, Ain Shams University.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

44_2018_2259_MOESM1_ESM.docx (9.7 mb)
Supplementary Information

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Hany M. Hassanin
    • 1
  • Wafaa R. Abd Elmoneam
    • 1
  • Mai A. Mostafa
    • 1
    Email author
  1. 1.Department of Chemistry, Faculty of EducationAin Shams University RoxyCairoEgypt

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