Cytotoxicity against cholangiocarcinoma and HepG2 cell lines of lignan derivatives from Hernandia nymphaeifolia
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Twelve lignan derivatives were synthesized from deoxypodophyllotoxin isolated from Hernandia nymphaeifolia. Cytotoxicity evaluation against cholangiocarcinoma, KKU-100, and HepG2 cell lines showed that compounds 3, 9, 10, and 13 exhibited stronger cytotoxicity than the starting material, 1, with IC50 ranging from 0.42 to 2.01 μM. Compound 10 displayed interesting activity by showing IC50 values of 0.75 and 0.46 μM against KKU-100 and HepG2 cell lines, respectively. From these observation, 10 seems to be useful as a lead compound for the development of anticancer agents.
KeywordsHernandia nymphaeifolia Deoxypodophyllotoxin KKU-100 HepG2
The Post-Doctoral Training Program from Research Affairs and Graduate School, Khon Kaen University for Jittra Suthiwong is acknowledged (Grant no. 590012). This work was supported by the Thailand Research Fund (RSA5980022), Khon Kaen University and The Center of Excellence for Innovation in Chemistry (PERCH-CIC), Office of the Higher Education Commission, Ministry of Education.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
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