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Medicinal Chemistry Research

, Volume 26, Issue 11, pp 3046–3056 | Cite as

Synthesis, in vitro evaluation of antibacterial, antifungal and larvicidal activities of pyrazole/pyridine based compounds and their nanocrystalline MS (M = Cu and Cd) derivatives

  • Gopinath Mondal
  • Harekrishna Jana
  • Moumita Acharjya
  • Ananyakumari Santra
  • Pradip Bera
  • Abhimanyu Jana
  • Anangamohan Panja
  • Pulakesh Bera
Original Research

Abstract

Methyl 3,5-dimethyl pyrazole-1-dithioate (mdpa) (1), benzyl 3,5-dimethyl pyrazole-1-dithioate (bdpa) (2), 3,5-dimethylpyrazole-1-(5methyl-1H-pyrazol-3-ylmethyl)-1H-pyrazole (3), copper(II)-mdpa (4), copper(II)-bdpa (5), cadmium(II)-mdpa (6), cadmium(II)-bdpa (7), Cu2S nanoparticles (8 and 9) derived from 4 and 5, respectively, CdS nanoparticles (10 and 11) derived from 6 and 7, respectively, were synthesized to screen their antimicrobial activities. Prolonged reaction with CuCl2.2H2O and 3 followed by addition of trace amount of pyridine furnished a crystalline chloro bridged complex [Cu(μ-Cl)2(pyridine)2]n and its structure was solved by single X-ray crystallography. Antibacterial activities of all of the synthesized materials (112) were evaluated against Gram positive bacteria including Staphylococcus aureus and Bacillus subtilis and Gram negative bacteria including Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Proteus vulgaris. Fungi (Candida albicans, Aspergillus flavus) were also used to test antifungal activities with the compounds. Present study revealed that 8 shows best antibacterial activity among the present reported compounds. An excellent antifugal activity is shown by 12 emerging to be a better antibiotic than standard fluconazole. Besides fungicidal effect, 12 has promising larvicidal effect. The structure and activity relationship has been discussed.

Keywords

Antibacterial Antifungal Larvicidal Pyrazole/Pyridine complexes Nanoparticles 

Notes

Acknowledgements

This investigation was supported by University grants Commission (UGC), Government of India for financial support (ref. grant no.-42-280/2013(SR)) and Council for Scientific and Industrial Research (CSIR) for the project grant (No.1(2858)/16/EMR-II). We are also thankful to Dr. Nandan Bhattacharyya, Principal, Panskura Banamali College, for providing instruments for biological assay.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

44_2017_2002_MOESM1_ESM.doc (10.8 mb)
Supplementary Information

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Post Graduate Department of Chemistry, Panskura Banamali CollegeVidyasagar UniversityMidnapore (E)India
  2. 2.Department of Microbiology, Panskura Banamali CollegeVidyasagar UniversityMidnapore (E)India

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