Prenyl-flavonoids from Epimedium koreanum Nakai and their soluble epoxide hydrolase and tyrosinase inhibitory activities
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A new 8-prenyl-flavonoid, epimedokoreanoside III, and 11 other flavonoids, were isolated from the aerial parts of Epimedium koreanum Nakai. Their chemical structures were elucidated by nuclear magnetic resonance and mass analyzes. All isolates were evaluated for their soluble epoxide hydrolase and tyrosinase inhibitory activities. Among the isolates, compounds 1, 5, 9, 10, and 12 exerted soluble epoxide hydrolase inhibitory activity in dose-dependent manner, with IC50 values ranging from 26.0 ± 1.2 to 37.6 ± 1.0 µM, whereas compounds 4 and 9 showed potent inhibition of tyrosinase in a dose-dependent manner, having IC50 values of 16.8 ± 2.7 and 8.7 ± 2.7 µM, respectively.
KeywordsEpimedium koreanum Nakai Berberidaceae Flavonoids Soluble epoxide hydrolase Tyrosinase
This work was supported by research fund of Chuangnam National University, and also supported by a grant (K17281) awarded to the Korean Institute of Oriental Medicine by the Ministry of Education, Science and Technology (MEST).
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Conflict of interest
The authors declare that they have no competing interests.
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