Phytochemical characterization and biological activity of secondary metabolites from three Limonium species
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The comparative phytochemical constituents of three Limonium species Limonium myrianthum, Limonium leptophyllum, and Limonium gmelinii afforded a new compound (2R,3S)-2,3,4-trihydroxy-2-methylbutyl gallate (1) and twenty known compounds (2–21). Each species displayed different profiles in their phytochemical constituents. The isolated compounds (1–21) were evaluated for antifungal, antimalarial, and antitrypanosomal activities. Compound 1 showed good activity against chloroquine-resistant and chloroquine-sensitive strains of malaria, while compound 5 displayed moderate antimalarial activity. Compound 14 showed a significant activity against Trypanosoma brucei.
KeywordsPlumbaginaceae Limonium Antifungal Antimalarial Antitrypanosomal
We are grateful to the Government of the Republic of Kazakhstan and the National Center for Natural Products Research (NCNPR), University of Mississippi, School of Pharmacy, USA for financial support. Also we are grateful to Dr. Melissa Jacob, Dr. Shabana Khan, and Dr. Babu Tekwani for performing antibacterial, antifungal, antimalarial, and antileishmanial bioassays.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
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