Medicinal Chemistry Research

, Volume 26, Issue 10, pp 2557–2567 | Cite as

Synthesis, antitubercular and antimicrobial potential of some new thiazole substituted thiosemicarbazide derivatives

  • Yogita K. Abhale
  • Abhijit Shinde
  • Keshav K. Deshmukh
  • Laxman Nawale
  • Dhiman Sarkar
  • Pravin C. MhaskeEmail author
Original Research


The increase in antibiotic resistance due to multiple factors has warranted the need for search of new compounds which are active against multidrug resistant pathogens. In this context a small focused library of thiosemicarbazide derivatives of 2-arylthiazole-4-carbaldehyde, 4-methyl-2-arylthiazole-5-carbaldehyde and 1-(4-methyl-2-arylthiazol-5-yl) ethanone, (5al) has been synthesized. The title compounds were screened for inhibitory activity against Mycobacterium tuberculosis H37Ra (ATCC 25177) and Mycobacterium bovis Bacille Calmette Guerin (ATCC 35743) strains. The synthesized compounds, 5al were further assayed for their cytotoxic activity against the two human cancer cell lines, HeLa and human colon carcinoma 116 cell lines and showed no significant cytotoxic activity against these two cell lines at the maximum concentration evaluated. Further, the synthesized compounds were found to have potential antibacterial activity against Gram-negative bacteria, Escherichia coli, Pseudomonas flurescence and Gram-positive bacteria, Staphylococcus aureus, Bacillus subtilis. Most of the synthesized compounds showed moderate activity against fungal strain Candida albicans. This study provides valuable directions to our ongoing endeavor of rationally designing more potent antimycobacterial agent.


Thiosemicarbazide Thiazole Antitubercular activity Antimicrobial activity Cytotoxicity 



Y.K.A. expresses her gratefulness to CSIR [File No. 08/590(0001)/2012-EMR-I] for the financial support. P.C.M. would like to thank University Grant Commission (UGC No. 42-355/2013(SR), New Delhi, India for the financial assistance and CSIR-NCL, Pune for supporting biological activity. Central Analysis facility, Savitribai Phule Pune University, Pune is also acknowledged for spectral analysis.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

44_2017_1955_MOESM1_ESM.docx (1.4 mb)
Supplementary Information


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Yogita K. Abhale
    • 1
  • Abhijit Shinde
    • 2
  • Keshav K. Deshmukh
    • 1
  • Laxman Nawale
    • 3
  • Dhiman Sarkar
    • 3
  • Pravin C. Mhaske
    • 2
    Email author
  1. 1.Post-Graduate Department of Chemistry and Research Centre, S. N. Arts, D. J. M. Commerce and B. N. S. Science CollegeSavitribai Phule Pune UniversitySangamnerIndia
  2. 2.Post Graduate Department of Chemistry, S. P. Mandali’s Sir Parashurambhau CollegeSavitribai Phule Pune UniversityPuneIndia
  3. 3.CombiChemBio Resource CentreCSIR-National Chemical LaboratoryPuneIndia

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