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Medicinal Chemistry Research

, Volume 26, Issue 5, pp 1010–1021 | Cite as

Synthesis, antimicrobial, and anti-inflammatory activities of acetamido pyrrolyl azoles

  • Donthamsetty V. Sowmya
  • Shaik Sharafuddin Basha
  • Palampalli Uma Maheswari Devi
  • Yerraguravagari Lavanyalatha
  • Adivireddy Padmaja
  • Venkatapuram Padmavathi
Original Research

Abstract

The acetamido pyrrolyl oxazoles/thiazoles/imidazoles were prepared and tested for their antimicrobial and anti-inflammatory activities. The nitro substituted acetamido pyrrolyl thiazole (11f) and pyrrolyl imidazole (12f) exhibited promising antibacterial activity against K. pneumoniae. The compound 12f showed good antifungal activity against P. chrysogenum. The methoxy acetamido pyrrolyl oxazole (10c) displayed potential anti-inflammatory activity.

Keywords

Pyrrole Oxazole Thiazole Imidazole Antimicrobial activity Anti-inflammatory activity 

Notes

Acknowledgements

The authors are grateful to BRNS (Board of Research in Nuclear Sciences) Trombay, Mumbai - 400085 for financial assistance under major research project.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

44_2017_1801_MOESM1_ESM.doc (12.5 mb)
Supplementary Information

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Donthamsetty V. Sowmya
    • 1
  • Shaik Sharafuddin Basha
    • 1
  • Palampalli Uma Maheswari Devi
    • 2
  • Yerraguravagari Lavanyalatha
    • 2
  • Adivireddy Padmaja
    • 1
  • Venkatapuram Padmavathi
    • 1
  1. 1.Sri Venkateswara UniversityTirupatiIndia
  2. 2.Sri Padmavathi MahilavisvavidyalayamTirupatiIndia

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