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Medicinal Chemistry Research

, Volume 26, Issue 3, pp 631–639 | Cite as

Effect of citral and citral related compounds on viability of pancreatic and human B-lymphoma cell lines

  • Antonia Di MolaEmail author
  • Antonio Massa
  • Vincenzo De Feo
  • Anna Basile
  • Maria Pascale
  • Rita Patrizia Aquino
  • Paolo De CaprariisEmail author
Original Research

Abstract

Citral, 3,7-dimethyl-2,6-octadienal, is a key component of the essential oils extracted from several lemon-scented herbal plants. It has been demonstrated to be an effective antifungal agent and in recent years, to have antiproliferative effect in certain tumor cell lines: thus citral could be a potential anticancer drug. In this study, we investigated the effect of citral on the proliferation of pancreatic cell tumor lines (MIA PaCa-2 cells) and human B-lymphoma (DeFew cells). To analyze which part of the molecule is pivotal for the activity, we also studied the effect of several citral related compounds, in particular focusing on some chemical aspects of the terpenic scaffold. The in vitro studies revealed the significant cytotoxic activity of some of the tested compounds.

Keywords

Citral Viability Mia PaCa-2 cells DeFew cells 

Notes

Acknowledgements

Thanks are due to university of Salerno for financial support.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Supplementary material

44_2017_1779_MOESM1_ESM.docx (748 kb)
Supplementary Information

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Antonia Di Mola
    • 1
    Email author
  • Antonio Massa
    • 2
  • Vincenzo De Feo
    • 1
  • Anna Basile
    • 3
  • Maria Pascale
    • 1
  • Rita Patrizia Aquino
    • 1
  • Paolo De Caprariis
    • 1
    Email author
  1. 1.Dipartimento di FarmaciaUniversità di SalernoFiscianoItaly
  2. 2.Dipartimento di Chimica e BiologiaUniversità di SalernoFiscianoItaly
  3. 3.Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”Università di SalernoBaronissiItaly

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