Medicinal Chemistry Research

, Volume 25, Issue 11, pp 2567–2577 | Cite as

Protective effects of three luteolin derivatives on aflatoxin B1-induced genotoxicity on human blood cells

  • Furkan Orhan
  • Selçuk ÇekerEmail author
  • Mustafa Anar
  • Guleray Agar
  • Tulin Arasoglu
  • Medine Gulluce
Original Research


In the present study, we aimed to investigate the genotoxic and anti-genotoxic potencies of three luteolin derivatives (luteolin-7-O-glucoside, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide) by using human cells. In the micronucleus test, the human lymphocytes were exposed to aflatoxin B1, the luteolin derivatives and a mixture of the two for 72 h. Furthermore, we have evaluated the levels of antioxidants of human whole blood plasma in order to clarify the possible mechanisms that may contribute to the anti-genotoxic activity of the luteolin derivatives. According to the results obtained from the micronucleus test, the highest protection rates for luteolin-7-O-glucoside, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide against aflatoxin B1 were 32.09, 35.55 and 37.50 %, respectively. Similarly, these three luteolin derivatives ameliorated the level of antioxidants altered from aflatoxin B1.


Luteolin derivatives Anti-genotoxic potential Antioxidants Micronucleus 



This study was supported by The Scientific and Technological Research Council of Turkey

(TUBITAK: 107T203).

Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflicts of interest.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Furkan Orhan
    • 1
  • Selçuk Çeker
    • 1
    Email author
  • Mustafa Anar
    • 2
  • Guleray Agar
    • 3
  • Tulin Arasoglu
    • 4
  • Medine Gulluce
    • 3
  1. 1.Central Research and Application LaboratoriesAgri Ibrahim Cecen UniversityAgriTurkey
  2. 2.Faculty of Science, Department of Molecular Biology and GeneticsAtaturk UniversityErzurumTurkey
  3. 3.Faculty of Science, Department of BiologyAtaturk UniversityErzurumTurkey
  4. 4.Molecular Biology and GeneticsYıldız Technical UniversityIstanbulTurkey

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