Abstract
Kaurenoic acid is a diterpene isolated from copaiba oleo resin. Based on the reported moderate cytotoxic activity of kaurenoic acid, a series of amides and diols derivatives of kaurenoic acid were synthesized and their abilities to inhibit the growth of MCF-7 cells were evaluated. Among the derivatives, compound 2f was the most active with an IC50 of 7.84 µM.
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Acknowledgments
This research was supported by CAPES, CNPQ e FAPESP (process number: 2011/23028-2 and 2011/13630-7). We thank David Barlow for technical support and Bo San Tsao for proofreading this manuscript.
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Simão, M.R., Carneiro, L.J., dos Santos, R.A. et al. In vitro cytotoxicity study of ent-kaurenoic acid derivatives against human breast carcinoma cell line. Med Chem Res 25, 303–309 (2016). https://doi.org/10.1007/s00044-015-1483-9
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DOI: https://doi.org/10.1007/s00044-015-1483-9