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Medicinal Chemistry Research

, Volume 24, Issue 5, pp 1942–1951 | Cite as

Synthesis and anticancer activity evaluation of some acridine derivatives

  • Surbhi Arya
  • Anuj Kumar
  • Nikhil Kumar
  • Partha Roy
  • S. M. SondhiEmail author
Original Research

Abstract

9-Amino acridine derivatives (1a1h) on condensation with 9, 10-dihydroanthracene-9, 10-α, β-succinic anhydride (2) at room temperature gave condensation products (3a3h). Microwave-assisted condensation of 9-amino acridine derivatives (1a1d) with phthalic anhydride, cis 1,2,3,6-tetrahydrophthalimide, and 2,5-pyrroledione gave corresponding condensation products 4a4d, 5a5d & 6a6d, respectively, in good yields. All these compounds were screened for in vitro anticancer activity against five human cancer cell lines i.e., breast (T47D), lung (NCl H-522), colon (HCT-15), ovary (PA-1), and liver (Hep G2). Compounds 3a (breast T47D), 3 g (lung NCl H-522), 4a (liver Hep G2), and 6b (colon HCT-15) exhibited IC50 values 5.4, 4.2, 4.5, and 2.4 µM, respectively, and hence possess good anticancer activity.

Keywords

Synthesis Acridine derivatives Human cancer cell lines Anticancer 

Notes

Acknowledgments

We are thankful to technical staff of the Chemistry Department, I. I. T. Roorkee, for spectroscopic studies and elemental analysis. Thanks also due to Head I.I.C. for providing NMR facility. Ms. Surbhi Arya (SRF) to CSIR New Delhi and Mr. Anuj Kumar to MHRD, New Delhi are thankful for financial assistance.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Surbhi Arya
    • 1
  • Anuj Kumar
    • 1
  • Nikhil Kumar
    • 2
  • Partha Roy
    • 2
  • S. M. Sondhi
    • 1
    Email author
  1. 1.Department of ChemistryIndian Institute of Technology-RoorkeeRoorkeeIndia
  2. 2.Department of BiotechnologyIndian Institute of Technology-RoorkeeRoorkeeIndia

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