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Medicinal Chemistry Research

, Volume 23, Issue 12, pp 5110–5119 | Cite as

Effect of garlic and cabbage on healing of gastric ulcer in experimental rats

  • Taibi Ben HaddaEmail author
  • Naser A. ElSawyEmail author
  • Eslam A. M. Header
  • Yahia N. Mabkhot
  • Mohammad S. Mubarak
Original Research
  • 462 Downloads

Abstract

The effect of garlic (Allium sativum) and cabbage (Brassica oleracea var. capitata) extracts on the healing of gastric ulcer in experimental rats has been investigated. Thirty-three albino male rats (115 ± 4 g B.Wt. each) were used and divided into 6 groups (n = 6 rats); one was used as a negative control while the others were given aspirin orally (200 mg/kg B.Wt.). One of these groups was employed as a positive control and the others were administrated with 150 or 300 mg/kg B.Wt. doses of garlic and cabbage juice for 7 days. The length of the gastric ulcer, the volume of gastric juice, the total acidity, the pH value, the total bacterial count, and the histopathological changes of the stomach were examined. Results revealed that oral administration with both tested plant extracts reduced the length of gastric ulcer, the total acidity, the volume of gastric juice, the bacterial count, and the histopathological changes caused by aspirin. On the other hand, both aqueous plants extract increased the pH value of gastric juice. It is concluded that, garlic and cabbage extract could be used for healing acute gastric ulcer.

Keywords

Garlic (Allium sativumCabbage (Brassica oleracea var. capitata) juice Aspirin ulcer Histopathological changes pH value Bacterial count Gastric juice 

Notes

Acknowledgments

The authors extend their appreciation to the Deanship of Scientific Research at King Saud University for funding the work through the research group project Number RGP- VPP- 007.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Taibi Ben Hadda
    • 1
    Email author
  • Naser A. ElSawy
    • 2
    • 3
    Email author
  • Eslam A. M. Header
    • 4
    • 5
  • Yahia N. Mabkhot
    • 6
  • Mohammad S. Mubarak
    • 7
  1. 1.Laboratoire Chimie Matériaux, FSOUniversité Mohammed 1erOujdaMorocco
  2. 2.Department of Anatomy and Embryology, Faculty of MedicineZagazig UniversityZagazigEgypt
  3. 3.Department of Laboratory Medicine, Faculty of Applied Medical SciencesUmm Al Qura UniversityMakkahSaudi Arabia
  4. 4.Clinical Nutrition, Faculty of Applied Medical SciencesUmm Al Qura UniversityMakkahSaudi Arabia
  5. 5.Department of Nutrition and Food Science, Faculty of Home EconomicsMinufiya UniversityShebin El KomEgypt
  6. 6.Department of Chemistry, Faculty of ScienceKing Saud UniversityRiyadhSaudi Arabia
  7. 7.Department of ChemistryThe University of JordanAmmanJordan

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