Chromenone and quinolinone derivatives as potent antioxidant agents
The antioxidant activity (AOA) of three different classes of phenolic compounds viz chromen-2-ones, chromen-4-ones, and quinolin-2-ones was systematically studied using DPPH, ABTS, FRAP, and in vitro lipid peroxidation inhibition assays. The effect of incorporation of hydrophobic group on AOA was also studied. In DPPH, ABTS, and FRAP assays, the highest AOA was registered for the dihydroxy chromenones among all the phenolic derivatives. Presence of alkyl group led to reduction in AOA in the above three assays. However, in lipid peroxidation inhibition assay for selected compounds, incorporation of alkyl group led to enhancement in AOA. The AOA of few compounds was observed to be more than three times higher in comparison to standard “Trolox” in lipid peroxidation inhibitory assay.
KeywordsAntioxidant activity Chromen-2-ones Chromen-4-ones Quinolin-2-ones Lipid peroxidation inhibitory activity
We thank University of Delhi, Defence Research Development Organization (DRDO, India), Indo-German Science and Technology Center (IGSTC), and Council of Scientific and Industrial Research (CSIR) for financial support. The award of Junior/Senior Research Fellowships (JRF/SRF) by CSIR (to KC), University Grants Commission (to AKS at Delhi University) and by DRDO (to DAJ) is gratefully acknowledged.
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