Synthesis of halogenated derivatives of thymol and their antimicrobial activities
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In order to test the antibacterial and antifungal activities of different halogenated thymol derivatives, thymol has been converted into chlorothymol, dichlorothymol with N-chlorosuccinimide; monobromothymol, dibromothymol with N-bromosuccinimide; O-methylated iodothymol with ceric ammonium nitrate and iodine from methylated thymol. Among the different derivatives tested, 4-chlorothymol was found to be most active against Staphylococcus aureus and Staphylococcus epidermis at a concentration of 12.5 and 25 ppm, respectively. Also it was tested to be active against Candida albicans (AI).
KeywordsThymol derivatives N-Halosuccinimide Antibacterial activity Antifungal activity
The authors are thanks to Prof. Ram Rajasekhran, Ex-Director and Shri Sudeep Tandon, Head, Process Chemistry and Technology Department, Central Institute of Medicinal and Aromatic Plants, for his keen interest in the work.
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