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Medicinal Chemistry Research

, Volume 23, Issue 3, pp 1123–1147 | Cite as

Synthesis, characterization, biological activity, and 3D-QSAR studies on some novel class of pyrrole derivatives as antitubercular agents

  • Shrinivas D. Joshi
  • Uttam A. More
  • Sheshagiri R. Dixit
  • Haresh H. Korat
  • Tejraj M. Aminabhavi
  • Aravind M. Badiger
Original Research

Abstract

A new series of pyrrole derivatives have been designed, synthesized, and their structures have been elucidated along with the evaluation of antitubercular activity against Mycobacterium tuberculosis H37Rv using the microplate alamar blue assay method and antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, and Escherichia coli by broth micro-dilution assay method. Structural activity relationships and 3D-QSAR analysis have been carried out by Topomer Comparative Molecular Field Analysis (CoMFA). Training set of 42 and test set of 8 active compounds were used to develop the method that showed cross-validated correlation coefficient (q 2) of 0.815, standard error of prediction of 0.36, non-cross-validated correlation coefficient (r 2) of 0.973, and standard error of estimate of 0.14 with six components.

Graphical Abstract

Synthesis; spectral and 3D-QSAR studies; and antibacterial, antitubercular, and cytotoxic activities of a novel series of pyrrole derivatives are described.

Keywords

Pyrroles Antibacterial activity Antitubercular activity Broth dilution assay method Cytotoxicity Topomer CoMFA 

Notes

Acknowledgments

Authors immensely thank the Indian Council of Medical Research, New Delhi, India for financial support [File No. 64/4/2011-BMS, IRIS Cell No. 2010-08710]. We also thank Dr. V. H. Kulkarni, Principal and Mr. H. V. Dambal, President, S.E.T.’s College of Pharmacy, Dharwad, India, for providing facilities. We thank Dr. K. G. Bhat, Maratha Mandal’s Dental College, Hospital and Research Centre, Belgaum, India for providing facilities for antibacterial, antitubercular, and cytotoxic activities; Director, SAIF, Indian Institute of Technology, Chennai, Tamil Nadu, India and the Director, SAIF, Panjab University, Chandigarh, Panjab, India for providing the NMR and mass spectral data. We thank Mr. Shrikant A. Tiwari for his technical assistance.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Shrinivas D. Joshi
    • 1
  • Uttam A. More
    • 1
    • 2
  • Sheshagiri R. Dixit
    • 1
  • Haresh H. Korat
    • 1
  • Tejraj M. Aminabhavi
    • 1
  • Aravind M. Badiger
    • 3
  1. 1.Novel Drug Design and Discovery Laboratory, Department of Pharmaceutical ChemistryS.E.T.’s College of PharmacyHubli-DharwarIndia
  2. 2.Centre for Research and DevelopmentPrist UniversityThanjavurIndia
  3. 3.BDR Pharmaceuticals International Pvt. Ltd.BarodaIndia

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