Medicinal Chemistry Research

, Volume 23, Issue 2, pp 948–957 | Cite as

Synthesis of new thiazolo[3,2-b][1,2,4]triazole-6(5H)-one derivatives as potent analgesic and anti-inflammatory agents

  • Mohammad Javad Assarzadeh
  • Ali Almasirad
  • Abbas Shafiee
  • Mansur Nassiri Koopaei
  • Mohammad Abdollahi
Original Research

Abstract

A series of thiazolo[3,2-b][1,2,4]triazole-6(5H)-ones were synthesized and evaluated for their analgesic and anti-inflammatory activities. The structures of these compounds were supported by FT-IR, 1HNMR, and Mass spectra. All of the final compounds showed potent analgesic activity and the best compound 9d was 2.4 times more potent than mefenamic acid as the reference drug. In addition, most of them showed comparable or better anti-inflammatory activity in comparison with mefenamic acid and indomethacin. Moreover, compounds 9d, 9e, 9g, 9h, 9i, 9k, 9n, and 9o did not exhibit any significant ulcerogenic activity.

Keywords

Analgesic agents Anti-inflammatory activity Thiazolo-triazole Ulcerogenic activity 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Mohammad Javad Assarzadeh
    • 1
  • Ali Almasirad
    • 1
  • Abbas Shafiee
    • 2
  • Mansur Nassiri Koopaei
    • 1
  • Mohammad Abdollahi
    • 3
  1. 1.Department of Medicinal Chemistry, Pharmaceutical Sciences BranchIslamic Azad UniversityTehranIran
  2. 2.Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research CenterTehran University of Medical SciencesTehranIran
  3. 3.Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences Research CenterTehran University of Medical SciencesTehranIran

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