Medicinal Chemistry Research

, Volume 22, Issue 11, pp 5105–5111 | Cite as

Synthesis, NMR spectral studies and antimicrobial evaluation of some 2-(benzothiazol-2-yl)-1-(alkyl-2r,6c-diarylpiperidin-4-ylidine)hydrazine derivatives

  • J. John Francis Xavier
  • R. Venkateswaramoorthi
  • A. Kamaraj
  • K. Krishnasamy
Review Article
First Online:
Received:
Accepted:

Abstract

Substituted 2-(benzothiazol-2-yl)-1-(alkyl-2,6-diarylpiperidin-4-ylidine)hydrazines 10–17 were synthesized by the condensation of different 2r,6c-diarylpiperidin-4-ones 1–8 with 2-hydrazinobenzothiazole 9. All the synthesized compounds were investigated in solution and in the solid state by IR, 1H, 13C and 2D NMR spectral techniques. The structure–activity relationships were studied by the screening of the antimicrobial activity over a representative panel of bacterial and fungal strains using two-fold serial dilution method.

Keywords

2r,6c-Diarylpiperidin-4-one 2-Mercaptobenzothiazole Hydrazine hydrate NMR techniques Antibacterial activity Antifungal activity 
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Notes

Acknowledgments

We are grateful to RMMCH, Annamalai University, Chidambaram, Tamil Nadu, India, for providing the facilities for antibacterial and antifungal activities. We also wish to thank, The Director, SAIF, Indian Institute of Technology, Chennai, India for recording NMR spectra. One of the authors John Francis Xavier is thankful to the University Grants Commission, New Delhi, India for the financial assistance.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • J. John Francis Xavier
    • 1
  • R. Venkateswaramoorthi
    • 1
  • A. Kamaraj
    • 1
  • K. Krishnasamy
    • 1
  1. 1.Department of ChemistryAnnamalai UniversityAnnamalainagarIndia

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