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Medicinal Chemistry Research

, Volume 22, Issue 10, pp 4893–4908 | Cite as

Synthesis, cytotoxicity, and molecular properties prediction of novel 1,3-diarylpyrazole derivatives

  • Sultan Nacak Baytas
  • Nazan Inceler
  • Akın Yılmaz
Original Research

Abstract

A novel combinatorial library of ester and amide derivatives of 1,3-diarylpyrazoles was designed and synthesized. Anticancer activities of these compounds were assessed against MCF7, MDA-MB-231, HeLa, Raji, and HL60 human cancer cells by MTT assay. Out of these, compounds 4c and 5f were found as the most promising anticancer agents with IC50 values of 8.12 and 9.63 μM in Raji cells, respectively. All compounds exhibited suitable drug-like characteristics according to Lipinski’s rule.

Keywords

Synthesis Anticancer activity 1H-Pyrazoles Pyridine MTT 

Notes

Acknowledgments

This investigation was partially supported by Scientific Research Grant 02/2011-08, awarded by Gazi University BAP.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Sultan Nacak Baytas
    • 1
  • Nazan Inceler
    • 1
  • Akın Yılmaz
    • 2
  1. 1.Division of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of PharmacyGazi UniversityEtilerTurkey
  2. 2.Department of Medical Biology and Genetics, Faculty of MedicineGazi UniversityBeşevlerTurkey

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