Medicinal Chemistry Research

, Volume 21, Issue 12, pp 4463–4472 | Cite as

Synthesis, characterization and antimicrobial screening of hybrid molecules containing benzimidazole-pyrazole and pyridine nucleus

  • N. C. Desai
  • D. D. Pandya
  • V. V. Joshi
  • K. M. Rajpara
  • H. V. Vaghani
  • H. M. Satodiya
Original Research


The rising prevalence of multi-drug resistant Gram-positive, Gram-negative bacteria and fungi continues to provide momentum for search and development of novel active antimicrobial agents against these pathogens. In continuation to this, the present article deals with the synthesis and antimicrobial activity of a novel series of (3-(1H-benzo[d]imidazol-2-yl)-5-(aryl)-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-4-yl)methanones 4an, synthesized by the reaction of benzimidazolyl chalcones with isoniazide 3. The structures of synthesized compounds were elucidated on the basis of IR, NMR, and mass spectra. The newly synthesized compounds 4an were screened for their antimicrobial activity against different strains of bacteria and fungi using serial broth dilution method. Compounds 4d, 4f, 4h, and 4g were found to be most active with MIC of 25 μg/mL against selected bacterial strains. Compounds 4c, 4g, and 4n were found to be most active with MIC of 100 μg/mL against selected fungal strains.


Benzimidazole-pyrazole Pyridine Antibacterial screening Antifungal screening MIC 


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • N. C. Desai
    • 1
  • D. D. Pandya
    • 1
  • V. V. Joshi
    • 1
  • K. M. Rajpara
    • 1
  • H. V. Vaghani
    • 1
  • H. M. Satodiya
    • 1
  1. 1.Division of Medicinal Chemistry, Department of ChemistryMahatma Gandhi Campus, Bhavnagar UniversityBhavnagarIndia

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