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Medicinal Chemistry Research

, Volume 22, Issue 7, pp 3527–3535 | Cite as

Synthesis, characterization, and biological evaluation of novel thiazole and pyrazole derivatives of quinoline-4-carboxylic acid as potential antimicrobial agents

  • Abha BishnoiEmail author
  • Anil Kumar Tiwari
  • Suruchi Singh
  • Arun Sethi
  • Chandrakant Mani Tripathi
  • Bikram Banerjee
Original Research

Abstract

A series of quinoline-based heterocycles prepared and bioevaluated for their possible antimicrobial activity against a panel of gram-positive bacteria [Staphylococcus aureus (ATCC-9144) and Bacillus subtilis (ATCC-6633)] and gram-negative bacteria [Pseudomonas aeruginosa (ATCC-25615), and Escherichia coli (MTCC-739)], and fungal strains [Candida albicans (ATCC-24433), Aspergillus niger (MTCC-872), and Aspergillus fumigatus (MTCC-343)] by the known methods. All the prepared quinoline derivatives have shown significant antimicrobial activities. Few compounds, viz. 4b, 4c and 4a, 4c proved to be active at low concentrations against Sa and Ca, respectively, while compounds 4a, 6d, and 6b showed milder inhibitory effects against other microbes. The structures of newly synthesized compounds were characterized by elemental analysis, Infrared (IR), 1HNMR, 13C-NMR and Mass-spectroscopy.

Keywords

Quinoline-4-carboxylic acid Acetophenone Thiosemicarbazide Polyphosphoric acid Antimicrobial activity 

Notes

Acknowledgments

The authors are thankful to the Head, Department of Chemistry, University of Lucknow, Lucknow for providing necessary Laboratory facilities and to the Director, Central Drug Research Institute (CDRI), Lucknow, India for providing spectral, elemental, and biological activity data.

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Abha Bishnoi
    • 1
    Email author
  • Anil Kumar Tiwari
    • 1
  • Suruchi Singh
    • 1
  • Arun Sethi
    • 1
  • Chandrakant Mani Tripathi
    • 2
  • Bikram Banerjee
    • 2
  1. 1.Department of ChemistryLucknow UniversityLucknowIndia
  2. 2.Division of Fermentation TechnologyCentral Drug Research InstituteLucknowIndia

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