Medicinal Chemistry Research

, Volume 22, Issue 6, pp 2737–2745 | Cite as

Antimicrobial activity of thiazolyl benzenesulfonamide-condensed 2,4-thiazolidinediones derivatives

  • Nikhil M. Parekh
  • Krunal V. Juddhawala
  • Bhaskar M. Rawal
Original Research

Abstract

A new series of benzoyl chloride-substituted 2,4-thiazolidinedione derivatives have been synthesized by the condensation of 2-amino-4-aryl-thiazole and 4′-chlorosulfonyl benzylidine-2,4-thiazolidinedione. New compounds were evaluated for their in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa. Furthermore, new products were tested for in vitro antituberculosis activity against Mycobacterium tuberculosis using isoniazid and rifampicin as control drugs. The results of bioassay demonstrated that some of the newly synthesized 2,4-thiazolidinedione derivatives emerged as lead molecules with excellent MIC (mg/mL) values against mentioned organisms compared to standard drugs. The structure of the final analogs has been confirmed on the basis of IR, 1H NMR, mass spectral, and elemental analysis.

Keywords

Thiazole 2,4-Thiazolidinedione Synthesis Antibacterial Antituberculosis 

Notes

Acknowledgments

The authors are thankful to the Department of Chemistry, Narmada College of Commerce and Science, Bharuch for providing research facility. The authors are also thankful to Prof. Dr. Bhaskar M. Rawal and Nikhil M. Parekh for their help during the research work.

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Nikhil M. Parekh
    • 1
  • Krunal V. Juddhawala
    • 2
  • Bhaskar M. Rawal
    • 2
  1. 1.Department of Applied ChemistryS. V. National Institute of TechnologySuratIndia
  2. 2.Department of ChemistryNarmada College of Science and CommerceZadeshwar, BharuchIndia

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