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Medicinal Chemistry Research

, Volume 22, Issue 1, pp 70–77 | Cite as

Evaluation of mefenamic acid mutual prodrugs

  • Kamal ShahEmail author
  • Sushant K. Shrivastava
  • Pradeep Mishra
Original Research

Abstract

Mutual prodrugs consisting of mefenamic acid with menthol and thymol have been synthesized as a gastrosparing NSAIDs, devoid of ulcerogenic side effects. The structures of synthesized esters were confirmed by IR, 1H NMR, and mass spectroscopy. The kinetics of ester hydrolysis was studied in nonenzymatic buffer solutions, at pH 2 and 7.4 as well as in human plasma by HPLC. Its anti-inflammatory, analgesic, and ulcerogenic activities were evaluated. Then biochemical parameters (GWM and Hexosamine), oxidative parameters (LPO, GSH, CAT, and SOD), and protein estimation was also done. The results indicated that synthesized prodrugs are chemically stable, biolabile, and posses optimum lipophilicity. The synthesized prodrugs are characterized by better ulcer index than the parent drug.

Keywords

Mutual prodrug Mefenamic acid Kinetics Ulcerogenic Oxidative stress parameters 

Notes

Acknowledgments

Authors thank M/S Zydus Cadila, Ahmedabad, Gujarat, India for providing mefenamic acid as gift sample and to Vice Chancellor, GLA University, Mathura UP, India for providing the research facilities to carry out this work in the Institute of Pharmaceutical Research.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Kamal Shah
    • 1
    Email author
  • Sushant K. Shrivastava
    • 2
  • Pradeep Mishra
    • 1
  1. 1.Department of Pharmaceutical Chemistry, Institute of Pharmaceutical ResearchGLA UniversityMathuraIndia
  2. 2.Department of Pharmaceutics, Institute of TechnologyBanaras Hindu UniversityVaranasiIndia

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