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Medicinal Chemistry Research

, Volume 21, Issue 12, pp 4301–4310 | Cite as

Synthesis, anti-microbial evaluation, and QSAR studies of 4-amino-3-hydroxy-naphthalene-1-sulfonic acid derivatives

  • Rajesh Kumar
  • Pradeep Kumar
  • Mahesh Kumar
  • Balasubramanian NarasimhanEmail author
Original Research

Abstract

A series of 4-amino-3-hydroxy-naphthalene-1-sulfonic acid derivatives (118) was synthesized and tested in vitro for its anti-microbial potential. The results of anti-microbial studies indicated that derivatives having 3,4,5 trimethoxy (6) and 2,4 dichloro (17) groups on benzylidene amino portion were found to be most effective ones. The mt-QSAR model for anti-microbial activity revealed the importance of topological parameter, valence zero-order molecular connectivity index (0χv) in describing the anti-microbial activity of synthesized 4-amino-3-hydroxy-naphthalene-1-sulfonic acid derivatives.

Keywords

Naphthalene-1-sulfonic acid derivatives Anti-microbial mt-QSAR 

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Rajesh Kumar
    • 1
  • Pradeep Kumar
    • 1
  • Mahesh Kumar
    • 1
  • Balasubramanian Narasimhan
    • 1
    Email author
  1. 1.Faculty of Pharmaceutical SciencesMaharshi Dayanand UniversityRohtakIndia

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