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Medicinal Chemistry Research

, Volume 21, Issue 9, pp 2702–2708 | Cite as

Synthesis, characterization and antimicrobial activity of novel ethyl 1-(N-substituted)-5-phenyl-1H-pyrazole-4-carboxylate derivatives

  • B. Chandrakantha
  • Arun M. IsloorEmail author
  • Prakash Shetty
  • Shrikrishna Isloor
  • Shridhar Malladi
  • Hoong Kun Fun
Original Research

Abstract

In the present study, a novel series of Pyrazole derivatives (3am) were synthesized by condensing ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate with different aromatic and aliphatic hydrazines. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral studies as well as by C, H, and N analyses. All the newly synthesized compounds were screened for their antibacterial properties against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa. Among the screened samples, 3c, 3f, 3k, and 3l have showed excellent antibacterial activity against all the tested bacterial strains as compared to the standard drug Ceftriaxone. Few of the compounds were found to be biologically potent. Molecular structure of compound 3i was confirmed by single crystal X-ray analysis.

Keywords

Pyrazole Antibacterial study MIC 

Notes

Acknowledgment

AMI is thankful to Board of Research in Nuclear Sciences, Department of Atomic Energy, Government of India for the “Yong Scientist” award.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • B. Chandrakantha
    • 1
  • Arun M. Isloor
    • 2
    Email author
  • Prakash Shetty
    • 3
  • Shrikrishna Isloor
    • 4
  • Shridhar Malladi
    • 2
  • Hoong Kun Fun
    • 5
  1. 1.Department of Chemistry, Manipal Institute of TechnologyManipal UniversityManipalIndia
  2. 2.Department of Chemistry, Organic Chemistry DivisionNational Institute of TechnologySurathkalIndia
  3. 3.Department of Printing, Manipal Institute of TechnologyManipal UniversityManipalIndia
  4. 4.Department of Microbiology, Veterinary CollegeVeterinary UniversityBangaloreIndia
  5. 5.X-ray Crystallography Unit, School of PhysicsUniversiti Sains MalaysiaUSM, PenangMalaysia

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