Medicinal Chemistry Research

, Volume 21, Issue 8, pp 2012–2022 | Cite as

Antimicrobial, analgesic, DPPH scavenging activities and molecular docking study of some 1,3,5-triaryl-2-pyrazolines

  • Seranthimata Samshuddin
  • Badiadka Narayana
  • Balladka Kunhanna Sarojini
  • Mahmud Tareq Hassan Khan
  • Hemmige S. Yathirajan
  • Chenna Govindaraju Darshan Raj
  • Ramappa Raghavendra
Original Research


A series of 1,3,5-triaryl-2-pyrazolines 2ag were synthesized by the reaction of 4,4′-disubstituted chalcone with phenyl hydrazine. All these compounds were characterized by NMR, IR and mass spectral and single crystal XRD data. All the synthesized products were screened for their in vitro antimicrobial, analgesic and antioxidant properties. The docking studies were carried out for these compounds against the active site of methionyl-tRNA synthetase (metRS). Some of the tested compounds exhibited significant antimicrobial, analgesic, DPPH scavenging activities and molecular binding.


Analgesic Antimicrobial DPPH scavenging assay 1,3,5-Triaryl-2-pyrazoline Molecular docking metRS Molecular recognition 



The authors are thankful to Mangalore University and the UGC-SAP for financial assistance for the purchase of chemicals. MTHK is grateful to Prof. Ingebrigt Sylte, Medical Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Science, University of Tromsø, N-9037 Tromsø, Norway, for the access of the license of ICM-Pro version.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Seranthimata Samshuddin
    • 1
  • Badiadka Narayana
    • 1
  • Balladka Kunhanna Sarojini
    • 2
  • Mahmud Tareq Hassan Khan
    • 3
  • Hemmige S. Yathirajan
    • 4
  • Chenna Govindaraju Darshan Raj
    • 2
  • Ramappa Raghavendra
    • 5
  1. 1.Department of Studies in ChemistryMangalore UniversityMangalagangotriIndia
  2. 2.Research Department of ChemistryP. A College of Engineering, NadupadavuMangaloreIndia
  3. 3.TromsøNorway
  4. 4.Department of Studies in ChemistryUniversity of MysoreMysoreIndia
  5. 5.Department of Postgraduate Studies and Research in BiochemistryJnana Sahyadri, Kuvempu UniversityShimogaIndia

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