Medicinal Chemistry Research

, Volume 21, Issue 8, pp 2064–2071 | Cite as

Syntheses and evaluation of 2,5-disubstituted 4-thiazolidinone analogues as antimicrobial agents

  • Pooja Chawla
  • Ranjit Singh
  • Shailendra K. SarafEmail author
Original Research


Two novel series of 4-thiazolidinone derivatives, bearing 2-nitrophenyl imino and 4-nitrophenyl imino groups at position-2 and substituted arylidene groups at position-5, have been synthesized and evaluated for antimicrobial activity against four bacterial and one fungal strain. The success of the synthesis of compounds was confirmed on the basis of spectral analysis. All the newly synthesized compounds were obtained in high yields and exhibited good antibacterial activity; however, the antifungal potential was limited to a few agents.


4-Thiazolidinones Arylidene Spectral analysis Antimicrobial 



The authors are thankful to Central Drug Research Institute, Lucknow, India for the library facility and spectral characterization.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Pooja Chawla
    • 1
  • Ranjit Singh
    • 2
  • Shailendra K. Saraf
    • 3
    Email author
  1. 1.Faculty of PharmacyBabu Banarasi Das National Institute of Technology and ManagementLucknowIndia
  2. 2.School of Pharmaceutical SciencesShobhit UniversityMeerutIndia
  3. 3.Faculty of PharmacyNorthern India Engineering CollegeLucknowIndia

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