Medicinal Chemistry Research

, Volume 21, Issue 8, pp 1929–1934 | Cite as

Substituted 2-[2-(pyridin-3-yl) phenyl] acetamides and ureas: design, synthesis, and anticonvulsant screening in mice

Original Research
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Abstract

Five novel 2-[2[(pyridin-3-yl) phenyl] acetamides and ureas were designed based on a two-point pharmacophore, synthesized by improved methods, and screened for anticonvulsant activity in maximal electroshock seizure (MES) and ScPTZ-induced seizure models in Swiss mice at doses of 30, 100, and 300 mg/kg body weight. Compound 15 displayed potent anticonvulsant activity in MES test with ED50 value of 8.28 mg/kg and higher protective index (TD50/ED50 = 26) compared with Phenytoin, which can be considered as a promising lead.

Keywords

Phenylacetamides Phenylacetylureas Pyridinylphenylacetamides MES test ScPTZ test 
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Notes

Acknowledgments

The authors are grateful to the Council of Scientific and Industrial Research (C.S.I.R.), Govt. of India for funding the project.

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Pharmaceutical ChemistryThe Bombay College of PharmacyMumbaiIndia

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