Synthesis, preliminary cytotoxicity evaluation of new 3-formylchromone hydrazones and phosphorohydrazone derivatives of coumarin and chromone
Reactions of chromone derivatives 1–4 with N-substituted hydrazines were described. Hydrazones (6, 7a, 8a–c, 9b–e, 10e, 11e, 12) were evaluated for cytotoxicity (MTT test) against HL-60 and NALM-6 leukemia cells. Phosphorohydrazone of 3-formylchromone 8a and hydrazone of 2-amino-3-chromone derivative 11e showed appreciable cytotoxicity. The cytotoxicity indices of 8a, 11e, and 12 were higher on drug-resistant HL-60 ADR cells in comparison to HL-60. Compounds 8a and 11e were tested for their ability to induce cytochrome c translocation from mitochondria to cytosol.
KeywordsChromone Hydrazone Cytotoxic Cytochrome c
This work was supported by the Medical University of Lodz (grants No 503/3-016-02/503-01, 503/3-015-02/503-01 and 503/3-016-03/503-01).
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