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Medicinal Chemistry Research

, Volume 21, Issue 8, pp 1861–1868 | Cite as

Synthesis, preliminary cytotoxicity evaluation of new 3-formylchromone hydrazones and phosphorohydrazone derivatives of coumarin and chromone

  • A. Łazarenkow
  • J. Nawrot-Modranka
  • E. Brzezińska
  • U. Krajewska
  • M. Różalski
Original Research

Abstract

Reactions of chromone derivatives 14 with N-substituted hydrazines were described. Hydrazones (6, 7a, 8ac, 9be, 10e, 11e, 12) were evaluated for cytotoxicity (MTT test) against HL-60 and NALM-6 leukemia cells. Phosphorohydrazone of 3-formylchromone 8a and hydrazone of 2-amino-3-chromone derivative 11e showed appreciable cytotoxicity. The cytotoxicity indices of 8a, 11e, and 12 were higher on drug-resistant HL-60 ADR cells in comparison to HL-60. Compounds 8a and 11e were tested for their ability to induce cytochrome c translocation from mitochondria to cytosol.

Keywords

Chromone Hydrazone Cytotoxic Cytochrome c 

Notes

Acknowledgments

This work was supported by the Medical University of Lodz (grants No 503/3-016-02/503-01, 503/3-015-02/503-01 and 503/3-016-03/503-01).

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • A. Łazarenkow
    • 1
  • J. Nawrot-Modranka
    • 1
  • E. Brzezińska
    • 2
  • U. Krajewska
    • 3
  • M. Różalski
    • 3
  1. 1.Chair of Medicinal Chemistry, Department of Bioinorganic Chemistry, Faculty of PharmacyMedical University of ŁódźLodzPoland
  2. 2.Chair of Medicinal Chemistry, Department of Analytical Chemistry, Faculty of PharmacyMedical University of ŁódźLodzPoland
  3. 3.Department of Pharmaceutical Biochemistry, Faculty of PharmacyMedical University of ŁódźLodzPoland

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