Investigation of myorelaxant activity of 9-aryl-3,4,6,7-tetrahydroacridine-1,8-(2H,5H,9H,10H)-diones in isolated rabbit gastric fundus
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- Fincan, G.S.Ö., Gündüz, M.G., Vural, İ.M. et al. Med Chem Res (2012) 21: 1817. doi:10.1007/s00044-011-9698-x
In this study, twelve compounds having 9-aryl-3,4,6,7-tetrahydroacridine-1,8-(2H,5H,9H,10H)-dione structure were synthesized by reaction of 5-methyl-1,3-cyclohexanedione, the appropriate aromatic aldehydes, and ammonium acetate in methanol. The structures of the compounds were elucidated by infrared, 1H- and 13C-nuclear magnetic resonance spectroscopy (-NMR), mass spectroscopy, and elemental analysis. The maximum relaxant effects (Emax) and pD2 values of the compounds 3a–l and pinacidil were tested on isolated strips of rabbit gastric fundus smooth muscle.