Medicinal Chemistry Research

, Volume 21, Issue 8, pp 1817–1824

Investigation of myorelaxant activity of 9-aryl-3,4,6,7-tetrahydroacridine-1,8-(2H,5H,9H,10H)-diones in isolated rabbit gastric fundus

  • Gökçe Sevim Öztürk Fincan
  • Miyase Gözde Gündüz
  • İsmail Mert Vural
  • Rahime Şimşek
  • Yusuf Sarıoğlu
  • Cihat Şafak
Original Research

DOI: 10.1007/s00044-011-9698-x

Cite this article as:
Fincan, G.S.Ö., Gündüz, M.G., Vural, İ.M. et al. Med Chem Res (2012) 21: 1817. doi:10.1007/s00044-011-9698-x

Abstract

In this study, twelve compounds having 9-aryl-3,4,6,7-tetrahydroacridine-1,8-(2H,5H,9H,10H)-dione structure were synthesized by reaction of 5-methyl-1,3-cyclohexanedione, the appropriate aromatic aldehydes, and ammonium acetate in methanol. The structures of the compounds were elucidated by infrared, 1H- and 13C-nuclear magnetic resonance spectroscopy (-NMR), mass spectroscopy, and elemental analysis. The maximum relaxant effects (Emax) and pD2 values of the compounds 3al and pinacidil were tested on isolated strips of rabbit gastric fundus smooth muscle.

Keywords

Myorelaxant activity Acridinedione Pinacidil 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Gökçe Sevim Öztürk Fincan
    • 1
  • Miyase Gözde Gündüz
    • 2
  • İsmail Mert Vural
    • 1
  • Rahime Şimşek
    • 2
  • Yusuf Sarıoğlu
    • 1
  • Cihat Şafak
    • 2
  1. 1.Department of Pharmacology, Faculty of MedicineGazi UniversityAnkaraTurkey
  2. 2.Department of Pharmaceutical Chemistry, Faculty of PharmacyHacettepe UniversityAnkaraTurkey

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